Diospyrin modulates inflammation in poly I: C-induced macrophages via ER stress-induced calcium-CHOP pathway
DC Field | Value | Language |
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dc.contributor.author | Kim, H.-J. | - |
dc.contributor.author | Khan, I. | - |
dc.contributor.author | Shahidullah, A. | - |
dc.contributor.author | Halimi, S.M.A. | - |
dc.contributor.author | Rauf, A. | - |
dc.contributor.author | Lee, J.-Y. | - |
dc.contributor.author | Kim, Y.-J. | - |
dc.contributor.author | Kim, B.-Y. | - |
dc.contributor.author | Park, W. | - |
dc.date.available | 2020-11-04T05:41:41Z | - |
dc.date.created | 2020-09-16 | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 2227-9717 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78850 | - |
dc.description.abstract | Diospyrin, plant-derived bisnaphthoquinonoid, is known to have anticancer activity. However, pharmacological activity of diospyrin on viral infection is not well known. We investigated effects of diospyrin on macrophages induced by polyinosinic-polycytidylic acid (poly I:C), a mimic of double-stranded viral RNA. Various cytokines, intracellular calcium, nitric oxide (NO), phosphorylated p38 MAPK, and phosphorylated ERK1/2 as well as mRNA expressions of transcription factors were evaluated. Diospyrin significantly reduced NO production, granulocyte-macrophage colony-stimulating factor production, and intracellular calcium release in poly I:C-induced RAW 264.7. The phosphorylation of p38 MAPK and ERK1/2 was also significantly suppressed. Additionally, diospyrin inhibited mRNA levels of nitric oxide synthase 2, C/EBP homologous protein (CHOP), calcium/calmodulin dependent protein kinase II alpha, signal transducers and activators of transcription 1 (STAT1), STAT3, STAT4, Janus kinase 2, first apoptosis signal receptor, c-Jun, and c-Fos in poly I:C-induced RAW 264.7. Taken together, this study represents that diospyrin might have the inhibitory activity against viral inflammation such as excessive production of inflammatory mediators in poly I:C-induced RAW 264.7 via ER stress-induced calcium-CHOP pathway. © 2020 by the authors. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | Processes | - |
dc.title | Diospyrin modulates inflammation in poly I: C-induced macrophages via ER stress-induced calcium-CHOP pathway | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000580684900001 | - |
dc.identifier.doi | 10.3390/pr8091050 | - |
dc.identifier.bibliographicCitation | Processes, v.8, no.9 | - |
dc.identifier.scopusid | 2-s2.0-85090425988 | - |
dc.citation.title | Processes | - |
dc.citation.volume | 8 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Kim, H.-J. | - |
dc.contributor.affiliatedAuthor | Lee, J.-Y. | - |
dc.contributor.affiliatedAuthor | Kim, Y.-J. | - |
dc.contributor.affiliatedAuthor | Kim, B.-Y. | - |
dc.contributor.affiliatedAuthor | Park, W. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Calcium | - |
dc.subject.keywordAuthor | CHOP | - |
dc.subject.keywordAuthor | Cytokine | - |
dc.subject.keywordAuthor | Diospyrin | - |
dc.subject.keywordAuthor | ER stress | - |
dc.subject.keywordAuthor | ERK1/2 | - |
dc.subject.keywordAuthor | P38 MAPK | - |
dc.subject.keywordAuthor | Poly I:C | - |
dc.subject.keywordAuthor | STAT | - |
dc.subject.keywordAuthor | Viral infection | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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