Combination therapy with oral treprostinil for pulmonary arterial hypertension: A double-blind placebo-controlled clinical trial
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dc.contributor.author | White R.J. | - |
dc.contributor.author | Jerjes-Sanchez C. | - |
dc.contributor.author | Meyer G.M.B. | - |
dc.contributor.author | Pulido T. | - |
dc.contributor.author | Sepulveda P. | - |
dc.contributor.author | Wang K.Y. | - |
dc.contributor.author | Grünig E. | - |
dc.contributor.author | Hiremath S. | - |
dc.contributor.author | Yu Z. | - |
dc.contributor.author | Zhang G. | - |
dc.contributor.author | Yip W.L.J. | - |
dc.contributor.author | Zhang S. | - |
dc.contributor.author | Khan A. | - |
dc.contributor.author | Deng C.Q. | - |
dc.contributor.author | Grover R. | - |
dc.contributor.author | Tapson V.F. | - |
dc.contributor.author | Svetliza G.N. | - |
dc.contributor.author | Lescano A.J. | - |
dc.contributor.author | Bortman G.R. | - |
dc.contributor.author | Diez F.A. | - |
dc.contributor.author | Botta C.E. | - |
dc.contributor.author | Fitzgerald J. | - |
dc.contributor.author | Feenstra E. | - |
dc.contributor.author | Kermeen F.D. | - |
dc.contributor.author | Keogh A.M. | - |
dc.contributor.author | Williams T.J. | - |
dc.contributor.author | Yousseff P.P. | - |
dc.contributor.author | Ng B.J.-H. | - |
dc.contributor.author | Smallwood D.M. | - |
dc.contributor.author | Dwyer N.B. | - |
dc.contributor.author | Brown M.R. | - |
dc.contributor.author | Lang I.M. | - |
dc.contributor.author | Steringer-Mascherbauer R. | - |
dc.contributor.author | Arakaki J.O. | - |
dc.contributor.author | Campos F. | - |
dc.contributor.author | De Amorim Correa R. | - |
dc.contributor.author | De Souza R. | - |
dc.contributor.author | Meyer G.M.B. | - |
dc.contributor.author | Moreira M.C. | - |
dc.contributor.author | Yoo H. | - |
dc.contributor.author | Lapa M.S. | - |
dc.contributor.author | Swiston J. | - |
dc.contributor.author | Hirani N. | - |
dc.contributor.author | Mehta S. | - |
dc.contributor.author | Michelakis E. | - |
dc.contributor.author | Sepulveda P. | - |
dc.contributor.author | Zagolin M. | - |
dc.contributor.author | Liu J. | - |
dc.contributor.author | Zhang S. | - |
dc.contributor.author | Pan L. | - |
dc.contributor.author | Chunde B. | - |
dc.contributor.author | Qun Y. | - |
dc.contributor.author | Cheng X. | - |
dc.contributor.author | Yu Z. | - |
dc.contributor.author | Li X. | - |
dc.contributor.author | Hua Y. | - |
dc.contributor.author | Zhang G. | - |
dc.contributor.author | Zhu X. | - |
dc.contributor.author | Chen Y. | - |
dc.contributor.author | Cheng Z. | - |
dc.contributor.author | Yang Y. | - |
dc.contributor.author | Zhou D. | - |
dc.contributor.author | Shen J. | - |
dc.contributor.author | Nielsen-Kudsk J.E. | - |
dc.contributor.author | Carlsen J. | - |
dc.contributor.author | Bourdin A. | - |
dc.contributor.author | Hachulla E. | - |
dc.contributor.author | Dromer C. | - |
dc.contributor.author | Chaouat A. | - |
dc.contributor.author | Reynaud-Gauber M. | - |
dc.contributor.author | Seronde M.-F. | - |
dc.contributor.author | Klose H. | - |
dc.contributor.author | Halank M. | - |
dc.contributor.author | Hoffken G. | - |
dc.contributor.author | Ewert R. | - |
dc.contributor.author | Rosenkranz S. | - |
dc.contributor.author | Grunig E. | - |
dc.contributor.author | Kruger U. | - |
dc.contributor.author | Kronsbein J. | - |
dc.contributor.author | Hauptmeier B.M. | - |
dc.contributor.author | Koch A. | - |
dc.contributor.author | Held M. | - |
dc.contributor.author | Lange T.J. | - |
dc.contributor.author | Neurohr C. | - |
dc.contributor.author | Wilkens H. | - |
dc.contributor.author | Wirtz H. | - |
dc.contributor.author | Konstantinides S. | - |
dc.contributor.author | Argyropoulou-Pataka P. | - |
dc.contributor.author | Orfanos S. | - |
dc.contributor.author | Hiremath S. | - |
dc.contributor.author | Kerkar P.G. | - |
dc.contributor.author | Suresh P.V. | - |
dc.contributor.author | Baxi H.A. | - |
dc.contributor.author | Oomman A. | - |
dc.contributor.author | Abhaichand R.K. | - |
dc.contributor.author | Edla Kumar P.K. | - |
dc.contributor.author | Chopra V. | - |
dc.contributor.author | Mehrotra R. | - |
dc.contributor.author | Rajput R.K. | - |
dc.contributor.author | Sawhney J.S. | - |
dc.contributor.author | Bimalendu S. | - |
dc.contributor.author | Sharma K.H. | - |
dc.contributor.author | Srinivasa Sastry B.K. | - |
dc.contributor.author | Kramer M.R. | - |
dc.contributor.author | Segel M.J. | - |
dc.contributor.author | Ben-Dov I. | - |
dc.contributor.author | Berkman N. | - |
dc.contributor.author | Yigla M. | - |
dc.contributor.author | Adir Y. | - |
dc.contributor.author | D'Alto M. | - |
dc.contributor.author | Vizza C.D. | - |
dc.contributor.author | Scelsi L. | - |
dc.contributor.author | Vitulo P. | - |
dc.contributor.author | Pulido T.R. | - |
dc.contributor.author | Jerjes-Sanchez C. | - |
dc.contributor.author | Boonstra A. | - |
dc.contributor.author | Vonk M.C. | - |
dc.contributor.author | Sobkowicz B. | - |
dc.contributor.author | Mularek-Kubzdela T. | - |
dc.contributor.author | Torbicki A. | - |
dc.contributor.author | Podolec P. | - |
dc.contributor.author | Teik L.S. | - |
dc.contributor.author | Yip W.L.J. | - |
dc.contributor.author | Chang H.-J. | - |
dc.contributor.author | Kim H.-K. | - |
dc.contributor.author | Park J.-B. | - |
dc.contributor.author | Chang S.-A. | - |
dc.contributor.author | Kim D.-K. | - |
dc.contributor.author | Chung W.-J. | - |
dc.contributor.author | Song J.-M. | - |
dc.contributor.author | Nissell M. | - |
dc.contributor.author | Hjalmarsson C. | - |
dc.contributor.author | Rundqvist B. | - |
dc.contributor.author | Huang W.-C. | - |
dc.contributor.author | Cheng C.-C. | - |
dc.contributor.author | Hsu C.-H. | - |
dc.contributor.author | Hsu H.-H. | - |
dc.contributor.author | Wang K.-Y. | - |
dc.contributor.author | Coghlan J.G. | - |
dc.contributor.author | Kiely D.G. | - |
dc.contributor.author | Pepke-Zaba J.W. | - |
dc.contributor.author | Lordan J.L. | - |
dc.contributor.author | Corris P.A. | - |
dc.contributor.author | Cadaret L. | - |
dc.contributor.author | Hansdottir S. | - |
dc.contributor.author | Oudiz R.J. | - |
dc.contributor.author | Badesch D.B. | - |
dc.contributor.author | Mathier M. | - |
dc.contributor.author | Schilz R. | - |
dc.contributor.author | Hill N. | - |
dc.contributor.author | Waxman A. | - |
dc.contributor.author | Markin C.J. | - |
dc.contributor.author | Zwicke D.L. | - |
dc.contributor.author | Fisher M. | - |
dc.contributor.author | Franco V. | - |
dc.contributor.author | Sood N. | - |
dc.contributor.author | Park M.H. | - |
dc.contributor.author | Allen R. | - |
dc.contributor.author | Feldman J.P. | - |
dc.contributor.author | Balasubramanian V. | - |
dc.contributor.author | Seeram V.K. | - |
dc.contributor.author | Bajwa A. | - |
dc.contributor.author | Thompson A.B. III | - |
dc.contributor.author | Migliore C. | - |
dc.contributor.author | Elwing J. | - |
dc.contributor.author | McConnell J.W. | - |
dc.contributor.author | Mehta J.P. | - |
dc.contributor.author | Rahaghi F.F. | - |
dc.contributor.author | Rame J.E. | - |
dc.contributor.author | Khan A. | - |
dc.contributor.author | Patel B. | - |
dc.contributor.author | Oren R.M. | - |
dc.contributor.author | Klinger J.R. | - |
dc.contributor.author | Alnuaimat H. | - |
dc.contributor.author | Allen S. | - |
dc.contributor.author | Harvey W. | - |
dc.contributor.author | Eggert M.S. | - |
dc.contributor.author | Hage A. | - |
dc.contributor.author | Miller C.E. | - |
dc.contributor.author | Awdish R. | - |
dc.contributor.author | Cajigas H. | - |
dc.contributor.author | Grinnan D. | - |
dc.contributor.author | Trichon B.H. | - |
dc.contributor.author | McDonough C. | - |
dc.contributor.author | White R.J. | - |
dc.contributor.author | Rischard F. | - |
dc.date.available | 2020-11-06T03:40:08Z | - |
dc.date.created | 2020-04-16 | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 1073-449X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78877 | - |
dc.description.abstract | Rationale: Oral treprostinil improves exercise capacity in patients with pulmonary arterial hypertension (PAH), but the effect on clinical outcomes was unknown. Objectives: To evaluate the effect of oral treprostinil compared with placebo on time to first adjudicated clinical worsening event in participants with PAH who recently began approved oral monotherapy. Methods: In this event-driven, double-blind study, we randomly allocated 690 participants (1:1 ratio) with PAH to receive placebo or oral treprostinil extended-release tablets three times daily. Eligible participants were using approved oral monotherapy for over 30 days before randomization and had a 6-minute-walk distance 150 m or greater. The primary endpoint was the time to first adjudicated clinical worsening event: death; hospitalization due to worsening PAH; initiation of inhaled or parenteral prostacyclin therapy; disease progression; or unsatisfactory long-term clinical response. Measurements and Main Results: Clinical worsening occurred in 26% of the oral treprostinil group compared with 36% of placebo participants (hazard ratio, 0.74; 95% confidence interval, 0.56–0.97; P = 0.028). Key measures of disease status, including functional class, Borg dyspnea score, and N-terminal pro–brain natriuretic peptide, all favored oral treprostinil treatment at Week 24 and beyond. A noninvasive risk stratification analysis demonstrated that oral treprostinil–assigned participants had a substantially higher mortality risk at baseline but achieved a lower risk profile from Study Weeks 12–60. The most common adverse events in the oral treprostinil group were headache, diarrhea, flushing, nausea, and vomiting. Conclusions: In participants with PAH, addition of oral treprostinil to approved oral monotherapy reduced the risk of clinical worsening. Copyright © 2020 by the American Thoracic Society | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | American Thoracic Society | - |
dc.relation.isPartOf | American Journal of Respiratory and Critical Care Medicine | - |
dc.title | Combination therapy with oral treprostinil for pulmonary arterial hypertension: A double-blind placebo-controlled clinical trial | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000519966100016 | - |
dc.identifier.doi | 10.1164/rccm.201908-1640OC | - |
dc.identifier.bibliographicCitation | American Journal of Respiratory and Critical Care Medicine, v.201, no.6, pp.707 - 717 | - |
dc.identifier.scopusid | 2-s2.0-85081891528 | - |
dc.citation.endPage | 717 | - |
dc.citation.startPage | 707 | - |
dc.citation.title | American Journal of Respiratory and Critical Care Medicine | - |
dc.citation.volume | 201 | - |
dc.citation.number | 6 | - |
dc.contributor.affiliatedAuthor | Chung W.-J. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Clinical study | - |
dc.subject.keywordAuthor | Combination therapy | - |
dc.subject.keywordAuthor | Oral treprostinil | - |
dc.subject.keywordAuthor | Pulmonary arterial hypertension | - |
dc.subject.keywordAuthor | Sequential therapy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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