Analysis and anticancer effects of active compounds from Spatholobi caulis in human breast cancer cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Phung, H.M. | - |
dc.contributor.author | Lee, H. | - |
dc.contributor.author | Lee, S. | - |
dc.contributor.author | Jang, D. | - |
dc.contributor.author | Kim, C.-E. | - |
dc.contributor.author | Kang, K.S. | - |
dc.contributor.author | Seo, C.-S. | - |
dc.contributor.author | Choi, Y.-K. | - |
dc.date.available | 2020-11-06T04:40:19Z | - |
dc.date.created | 2020-10-22 | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 2227-9717 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78884 | - |
dc.description.abstract | Breast cancer is the most common malignancy in both developing and developed countries. In this study, we simultaneously analyzed nine constituent compounds from Spatholobi Caulis (gallic acid, (-)-gallocatechin, 3,4-dihydroxybenzoic acid, procyanidin B1, 3,4-dihydroxybenzaldehyde, catechin, procyanidin B2, epicatechin, and (-)-epicatechin gallate) and examined their anticancer effects on MCF-7 and MDA-MB-231 human breast cancer cells. The experimental results indicated that the gallic acid showed the strongest cytotoxic effect on MCF-7 cells among tested compounds whilst most of samples did not express inhibitory effect on viability of MDA-MB-231 cells, except for 70% ethanol extract of S. Caulis. Thus, gallic acid was chosen to extend anticancer mechanism study on MCF-7 cells. Our data showed that the gallic acid induced apoptotic MCF-7 cell death through both extrinsic and intrinsic pathways, which increased the expression of cleaved caspase-7, -8, and -9, Bax and p53, but reduced the expression of Bcl-2 and poly (ADP-ribose) polymerase (PARP). In addition, the network pharmacological analysis pointed out that the p53, mitogen-activated protein kinase (MAPK), estrogen, and Wnt signaling pathways have a great correlation with the targets of gallic acid. This study suggested that gallic acid is a bioactive component of S. Caulis with potential to be used in chemotherapy for breast cancer. © 2020 by the authors. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | Processes | - |
dc.title | Analysis and anticancer effects of active compounds from Spatholobi caulis in human breast cancer cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000581984100001 | - |
dc.identifier.doi | 10.3390/PR8091193 | - |
dc.identifier.bibliographicCitation | Processes, v.8, no.9 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85092560568 | - |
dc.citation.title | Processes | - |
dc.citation.volume | 8 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Phung, H.M. | - |
dc.contributor.affiliatedAuthor | Lee, H. | - |
dc.contributor.affiliatedAuthor | Lee, S. | - |
dc.contributor.affiliatedAuthor | Jang, D. | - |
dc.contributor.affiliatedAuthor | Kim, C.-E. | - |
dc.contributor.affiliatedAuthor | Kang, K.S. | - |
dc.contributor.affiliatedAuthor | Choi, Y.-K. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Breast cancer | - |
dc.subject.keywordAuthor | Gallic acid | - |
dc.subject.keywordAuthor | MCF-7 | - |
dc.subject.keywordAuthor | Network pharmacology | - |
dc.subject.keywordAuthor | p53 | - |
dc.subject.keywordAuthor | Spatholobi Caulis | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.