Direct translation of climbing fiber burst-mediated sensory coding into post-synaptic Purkinje cell dendritic calcium
DC Field | Value | Language |
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dc.contributor.author | Roh, Seung-Eon | - |
dc.contributor.author | Kim, Seung Ha | - |
dc.contributor.author | Ryu, Changhyeon | - |
dc.contributor.author | Kim, Chang-Eop | - |
dc.contributor.author | Kim, Yong Gyu | - |
dc.contributor.author | Worley, Paul F. | - |
dc.contributor.author | Kim, Sun Kwang | - |
dc.contributor.author | Kim, Sang Jeong | - |
dc.date.available | 2020-11-18T00:40:47Z | - |
dc.date.created | 2020-11-18 | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 2050-084X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78962 | - |
dc.description.abstract | Climbing fibers (CFs) generate complex spikes (CS) and Ca2+ transients in cerebellar Purkinje cells (PCs), serving as instructive signals. The so-called 'all-or-none' character of CSs has been questioned since the CF burst was described. Although recent studies have indicated a sensory-driven enhancement of PC Ca2+ signals, how CF responds to sensory events and contributes to PC dendritic Ca2+ and CS remains unexplored. Here, single or simultaneous Ca2+ imaging of CFs and PCs in awake mice revealed the presynaptic CF Ca2+ amplitude encoded the sensory input's strength and directly influenced post-synaptic PC dendritic Ca2+ amplitude. The sensory-driven variability in CF Ca2+ amplitude depended on the number of spikes in the CF burst. Finally, the spike number of the CF burst determined the PC Ca2+ influx and CS properties. These results reveal the direct translation of sensory information-coding CF inputs into PC Ca2+, suggesting the sophisticated role of CFs as error signals. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELIFE SCIENCES PUBLICATIONS LTD | - |
dc.relation.isPartOf | ELIFE | - |
dc.title | Direct translation of climbing fiber burst-mediated sensory coding into post-synaptic Purkinje cell dendritic calcium | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000584991100001 | - |
dc.identifier.doi | 10.7554/eLife.61593 | - |
dc.identifier.bibliographicCitation | ELIFE, v.9 | - |
dc.identifier.scopusid | 2-s2.0-85092187488 | - |
dc.citation.title | ELIFE | - |
dc.citation.volume | 9 | - |
dc.contributor.affiliatedAuthor | Kim, Chang-Eop | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | LONG-TERM DEPRESSION | - |
dc.subject.keywordPlus | SUBTHRESHOLD OSCILLATIONS | - |
dc.subject.keywordPlus | SYNAPTIC PLASTICITY | - |
dc.subject.keywordPlus | CEREBELLAR | - |
dc.subject.keywordPlus | SIGNALS | - |
dc.subject.keywordPlus | INFORMATION | - |
dc.subject.keywordPlus | MODULATION | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | SPIKES | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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