Low High-Sensitivity C-Reactive Protein Level in Korean Patients With Chronic Kidney Disease and Its Predictive Significance for Cardiovascular Events, Mortality, and Adverse Kidney Outcomes: Results From KNOW-CKD
DC Field | Value | Language |
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dc.contributor.author | Lee, C. | - |
dc.contributor.author | Park, K.H. | - |
dc.contributor.author | Joo, Y.S. | - |
dc.contributor.author | Nam, K.H. | - |
dc.contributor.author | Chang, T.-I. | - |
dc.contributor.author | Kang, E.W. | - |
dc.contributor.author | Lee, J. | - |
dc.contributor.author | Oh, Y.K. | - |
dc.contributor.author | Jung, J.Y. | - |
dc.contributor.author | Ahn, C. | - |
dc.contributor.author | Lee, K.-B. | - |
dc.contributor.author | Park, J.T. | - |
dc.contributor.author | Yoo, T.-H. | - |
dc.contributor.author | Kang, S.-W. | - |
dc.contributor.author | Han, S.H. | - |
dc.date.available | 2020-11-25T00:40:15Z | - |
dc.date.created | 2020-11-13 | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 2047-9980 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/79064 | - |
dc.description.abstract | Background Inflammation levels are lower in East Asians than in Western people. We studied the association between high-sensitivity hs-CRP (C-reactive protein) and adverse outcomes in Korean patients with chronic kidney disease. Methods and Results We included 2018 participants from the KNOW-CKD (Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease) between April 2011 and February 2016. The primary outcome was a composite of extended major cardiovascular events (eMACE) or all-cause mortality. The secondary end points were separate outcomes of eMACE, all-cause death, and adverse kidney outcome. We also evaluated predictive ability of hs-CRP for the primary outcome. The median hs-CRP level was 0.60 mg/L. During the mean follow-up of 3.9 years, there were 125 (6.2%) eMACEs and 80 (4.0%) deaths. In multivariable Cox analysis after adjustment of confounders, there was a graded association of hs-CRP with the primary outcome. The hazard ratios for hs-CRPs of 1.0 to 2.99 and ≥3.0 mg/L were 1.33 (95% CI, 0.87-2.03) and 2.08 (95% CI, 1.30-3.33) compared with the hs-CRP of <1.0 mg/L. In secondary outcomes, this association was consistent for eMACE and all-cause death; however, hs-CRP was not associated with adverse kidney outcomes. Finally, prediction models failed to show improvement of predictive performance of hs-CRP compared with conventional factors. Conclusions In Korean patients with chronic kidney disease, the hs-CRP level was low and significantly associated with higher risks of eMACEs and mortality. However, hs-CRP did not associate with adverse kidney outcome, and the predictive performance of hs-CRP was not strong. Registration URL: http://www.clinicaltrials.gov; Unique identifier: NCT01630486. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.relation.isPartOf | Journal of the American Heart Association | - |
dc.title | Low High-Sensitivity C-Reactive Protein Level in Korean Patients With Chronic Kidney Disease and Its Predictive Significance for Cardiovascular Events, Mortality, and Adverse Kidney Outcomes: Results From KNOW-CKD | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000588373500005 | - |
dc.identifier.doi | 10.1161/JAHA.120.017980 | - |
dc.identifier.bibliographicCitation | Journal of the American Heart Association, v.9, no.21, pp.e017980 | - |
dc.identifier.scopusid | 2-s2.0-85095669419 | - |
dc.citation.startPage | e017980 | - |
dc.citation.title | Journal of the American Heart Association | - |
dc.citation.volume | 9 | - |
dc.citation.number | 21 | - |
dc.contributor.affiliatedAuthor | Jung, J.Y. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | cardiovascular events | - |
dc.subject.keywordAuthor | chronic kidney disease | - |
dc.subject.keywordAuthor | hs‐CRP | - |
dc.subject.keywordAuthor | kidney outcome | - |
dc.subject.keywordAuthor | mortality | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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