Fisetin Suppresses Pulmonary Inflammatory Responses through Heme Oxygenase-1 Mediated Downregulation of Inducible Nitric Oxide Synthase
DC Field | Value | Language |
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dc.contributor.author | Sim, Hyunchae | - |
dc.contributor.author | Choo, Samyeol | - |
dc.contributor.author | Kim, Jaehong | - |
dc.contributor.author | Baek, Moon-Chang | - |
dc.contributor.author | Bae, Jong-Sup | - |
dc.date.available | 2020-11-25T01:40:07Z | - |
dc.date.created | 2020-11-06 | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 1096-620X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/79071 | - |
dc.description.abstract | The effects of a mixture of fisetin on cytokine-mediated pulmonary damages have not been studied, despite its known antiviral, neuroprotective, and anti-inflammatory activities. Using lipopolysaccharide (LPS)-activated human pulmonary artery endothelial cells (HPAECs), we determined the effects of fisetin on the induction of heme oxygenase-1 (HO-1), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2). In the lung tissue of LPS-treated mice, fisetin was also evaluated for its effect on the regulation of iNOS and tumor necrosis factor (TNF)-alpha. In LPS-activated HPAECs, fisetin increased nuclear factor erythrocyte 2-related factor 2-antioxidant response element (Nrf2-ARE) reporter activity through the nuclear translocation of Nrf2, and the expression of HO-1, and decreased IL-1 beta and iNOS/NO production. In particular, the suppression of iNOS/NO expression by the administration of fisetin was dependent on HO-1. Current findings indicate that the anti-inflammatory activity of fisetin was due to its HO-1 dependent downregulation of p-STAT-1 and nuclear factor kappa B (NF-kappa B) and the resultant inhibition of iNOS, and also suggest TNF-alpha as a potential target for HO-1. We propose that administration of fisetin may be a novel approach, ideal for the treatment of inflammatory pulmonary disease. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.relation.isPartOf | JOURNAL OF MEDICINAL FOOD | - |
dc.title | Fisetin Suppresses Pulmonary Inflammatory Responses through Heme Oxygenase-1 Mediated Downregulation of Inducible Nitric Oxide Synthase | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000581776000001 | - |
dc.identifier.doi | 10.1089/jmf.2020.4755 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MEDICINAL FOOD, v.23, no.11, pp.1163 - 1168 | - |
dc.identifier.kciid | ART002652630 | - |
dc.identifier.scopusid | 2-s2.0-85096079836 | - |
dc.citation.endPage | 1168 | - |
dc.citation.startPage | 1163 | - |
dc.citation.title | JOURNAL OF MEDICINAL FOOD | - |
dc.citation.volume | 23 | - |
dc.citation.number | 11 | - |
dc.contributor.affiliatedAuthor | Kim, Jaehong | - |
dc.type.docType | Article; Early Access | - |
dc.subject.keywordAuthor | fisetin | - |
dc.subject.keywordAuthor | HO-1 | - |
dc.subject.keywordAuthor | iNOS | - |
dc.subject.keywordAuthor | p-STAT-1 | - |
dc.subject.keywordPlus | CARBON-MONOXIDE | - |
dc.subject.keywordPlus | KAPPA-B | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | COX-2 | - |
dc.subject.keywordPlus | MODEL | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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