Identification of Anti-Inflammatory Compounds from Hawaiian Noni (Morinda citrifolia L.) Fruit Juice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, D. | - |
dc.contributor.author | Yu, J.S. | - |
dc.contributor.author | Huang, P. | - |
dc.contributor.author | Qader, M. | - |
dc.contributor.author | Manavalan, A. | - |
dc.contributor.author | Wu, X. | - |
dc.contributor.author | Kim, J.-C. | - |
dc.contributor.author | Pang, C. | - |
dc.contributor.author | Cao, S. | - |
dc.contributor.author | Kang, K.S. | - |
dc.contributor.author | Kim, K.H. | - |
dc.date.available | 2020-11-30T00:41:21Z | - |
dc.date.created | 2020-11-11 | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/79109 | - |
dc.description.abstract | Noni (Morinda citrifolia L.) fruit juice has been used in Polynesia as a traditional folk medicine and is very popular worldwide as a functional food supplement. In this study, compounds present in Hawaiian Noni fruit juice, with anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells were identified. Five compounds were isolated using a bioassay-driven technique and phytochemical analysis of noni fruit juice: asperulosidic acid (1), rutin (2), nonioside A (3), (2E,4E,7Z)-deca-2,4,7-trienoate-2-O-β-d-glucopyranosyl-β-d-glucopyranoside (4), and tricetin (5). The structures of these five compounds were determined via NMR spectroscopy and LC/MS. In an anti-inflammatory assay, compounds 1-5 inhibited the production of nitric oxide (NO), which is a proinflammatory mediator, in LPS-stimulated macrophages. Moreover, the mechanisms underlying the anti-inflammatory effects of compounds 1-5 were investigated. Parallel to the inhibition of NO production, treatment with compounds 1-5 downregulated the expression of IKKα/β, I-κBα, and NF-κB p65 in LPS-stimulated macrophages. Furthermore, treatment with compounds 1-5 downregulated the expression of nitric oxide synthase and cyclooxygenase-2. Thus, these data demonstrated that compounds 1-5 present in noni fruit juice, exhibited potential anti-inflammatory activity; these active compounds may contribute preventively and therapeutically against inflammatory diseases. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | Molecules (Basel, Switzerland) | - |
dc.title | Identification of Anti-Inflammatory Compounds from Hawaiian Noni (Morinda citrifolia L.) Fruit Juice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000589283800001 | - |
dc.identifier.doi | 10.3390/molecules25214968 | - |
dc.identifier.bibliographicCitation | Molecules (Basel, Switzerland), v.25, no.21 | - |
dc.identifier.scopusid | 2-s2.0-85095405078 | - |
dc.citation.title | Molecules (Basel, Switzerland) | - |
dc.citation.volume | 25 | - |
dc.citation.number | 21 | - |
dc.contributor.affiliatedAuthor | Lee, D. | - |
dc.contributor.affiliatedAuthor | Kang, K.S. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | anti-inflammation | - |
dc.subject.keywordAuthor | Morinda citrifolia | - |
dc.subject.keywordAuthor | NO production | - |
dc.subject.keywordAuthor | noni | - |
dc.subject.keywordAuthor | RAW 264.7 cells | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.