Ameliorative effects of Juniperus rigida fruit on oxazolone- and 2,4-dinitrochlorobenzene-induced atopic dermatitis in mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Sullim | - |
dc.contributor.author | Park, No-June | - |
dc.contributor.author | Bong, Sim-Kyu | - |
dc.contributor.author | Jegal, Jonghwan | - |
dc.contributor.author | Park, Sang-a | - |
dc.contributor.author | Kim, Su-Nam | - |
dc.contributor.author | Yang, Min Hye | - |
dc.date.available | 2020-12-02T05:40:05Z | - |
dc.date.created | 2020-12-02 | - |
dc.date.issued | 2018-03 | - |
dc.identifier.issn | 0378-8741 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/79168 | - |
dc.description.abstract | Ethnopharmacological relevance: The fruits of Juniperus rigida have been used in Korean traditional medicine for the treatment of inflammatory diseases in humans such as rheumatoid arthritis. Aim of the study: This study aimed to investigate the anti-atopic properties of J. rigida fruit in in vivo murine atopic dermatitis (AD) models. Methods and results: BALB/c mouse ears ad SKH-1 hairless mice stimulated with oxazolone (4 weeks) and DNCB (3 weeks), respectively, were treated with the 1% Juniperus rigida fruit EtOH extract (JFE). The JFE improved AD symptoms in both oxazolone- and DNCB-induced AD mice by accelerating skin barrier recovery function and suppressing the overproduction of serum immunoglobulin E (IgE) and interleukin 4 (IL-4). The JFE was found to contain isoscutellarein-7-O-beta-xylopyranoside, cupressuflavone, podocarpusflavone A, and hinokiflavone as major components based on phytochemical analysis. Eight flavonoids were isolated from JFE, and of those, cupressuflavone and isoscutellarein-7-O-beta-xylopyranoside strongly down-regulated IL-4 expression and P-hexosaminidase release in RBL-2H3 cells. Conclusion: Therapeutic attempts with J. rigida fruit and its active components might be useful in treating AD and related skin inflammatory diseases. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.relation.isPartOf | JOURNAL OF ETHNOPHARMACOLOGY | - |
dc.title | Ameliorative effects of Juniperus rigida fruit on oxazolone- and 2,4-dinitrochlorobenzene-induced atopic dermatitis in mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000426230900019 | - |
dc.identifier.doi | 10.1016/j.jep.2017.12.022 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ETHNOPHARMACOLOGY, v.214, pp.160 - 167 | - |
dc.identifier.scopusid | 2-s2.0-85038405073 | - |
dc.citation.endPage | 167 | - |
dc.citation.startPage | 160 | - |
dc.citation.title | JOURNAL OF ETHNOPHARMACOLOGY | - |
dc.citation.volume | 214 | - |
dc.contributor.affiliatedAuthor | Lee, Sullim | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Juniperus rigida fruit | - |
dc.subject.keywordAuthor | Atopic dermatitis | - |
dc.subject.keywordAuthor | Skin barrier function | - |
dc.subject.keywordAuthor | Interleukin 4 | - |
dc.subject.keywordAuthor | Cupressuflavone | - |
dc.subject.keywordAuthor | lsoscutellarein-7-O-beta-xylopyranoside | - |
dc.subject.keywordPlus | CONTACT HYPERSENSITIVITY | - |
dc.subject.keywordPlus | STRATUM-CORNEUM | - |
dc.subject.keywordPlus | HAIRLESS MOUSE | - |
dc.subject.keywordPlus | IGE SYNTHESIS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | BIFLAVONOIDS | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.