Outcomes and Risk Factors of Systolic Pulmonary Artery Pressure Progression in Patients With Systemic Rheumatic Diseases: Follow-up Results from a Korean Registry
DC Field | Value | Language |
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dc.contributor.author | Seo, Mi Ryoung | - |
dc.contributor.author | Yeo, Jina | - |
dc.contributor.author | Ryu, Hee Jung | - |
dc.contributor.author | Choi, Hyo-jin | - |
dc.contributor.author | Ko, Kwang-pil | - |
dc.contributor.author | Baek, Han Joo | - |
dc.date.available | 2020-12-21T00:40:49Z | - |
dc.date.created | 2020-12-15 | - |
dc.date.issued | 2020-12 | - |
dc.identifier.issn | 2148-5046 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/79382 | - |
dc.description.abstract | Objectives: This study aims to investigate the outcomes and risk factors associated with the progression of systolic pulmonary artery pressure (sPAP) in patients with systemic rheumatic diseases. Patients and methods: A total of 532 patients (73 males, 459 females; median age 49 years; interquartile range (IQR), 36 to 62 years) registered with the Registry of Pulmonary Hypertension Associated with Rheumatic Diseases were included. Mortality curves were constructed using the Kaplan-Meier method and comparisons were performed using the log-rank test. A paired t-test was performed to evaluate the patients with markedly elevated sPAP between baseline and follow-up. Results: The average follow-up duration was 31 months (IQR, 9 to 60 months). Of the patients, 196 had follow-up echocardiographs at least one year later. We defined the sPAP over 60 mmHg as markedly elevated. Patients in the increased sPAP above 60 mmHg at follow-up and persistently markedly elevated sPAP were associated with worse outcomes in all-cause mortality and pulmonary arterial hypertension-related mortality (p<0.001). In patients with systemic sclerosis, the majority of patients remained static within their pressure group or rose progressively: the patients with markedly elevated sPAP at follow-up were higher than those at baseline (32% versus 15%, p<0.01). In patients with mixed connective tissue disease (MCTD) or rheumatoid arthritis (RA), the majority of patients remained static within their pressure group or gradually improved: the patients with markedly elevated sPAP at follow-up were lower than those at baseline (RA=14% versus 29%, MCTD=5% versus 16%, p<0.05). Conclusion: Persistently high sPAP or increase of sPAP over 60 mmHg at follow-up was associated with increased mortality. There were some differences in the progression of sPAP according to the underlying rheumatic diseases. © 2020 Turkish League Against Rheumatism. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Turkish League Against Rheumatism (TLAR) | - |
dc.relation.isPartOf | Archives of Rheumatology | - |
dc.title | Outcomes and Risk Factors of Systolic Pulmonary Artery Pressure Progression in Patients With Systemic Rheumatic Diseases: Follow-up Results from a Korean Registry | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000595829400011 | - |
dc.identifier.doi | 10.46497/ArchRheumatol.2020.7812 | - |
dc.identifier.bibliographicCitation | Archives of Rheumatology, v.35, no.4, pp.558 - 567 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85097179610 | - |
dc.citation.endPage | 567 | - |
dc.citation.startPage | 558 | - |
dc.citation.title | Archives of Rheumatology | - |
dc.citation.volume | 35 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Seo, Mi Ryoung | - |
dc.contributor.affiliatedAuthor | Yeo, Jina | - |
dc.contributor.affiliatedAuthor | Ryu, Hee Jung | - |
dc.contributor.affiliatedAuthor | Choi, Hyo-jin | - |
dc.contributor.affiliatedAuthor | Ko, Kwang-pil | - |
dc.contributor.affiliatedAuthor | Baek, Han Joo | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Connective tissue diseases | - |
dc.subject.keywordAuthor | Hypertension | - |
dc.subject.keywordAuthor | Prognosis | - |
dc.subject.keywordAuthor | Pulmonary | - |
dc.subject.keywordAuthor | Rheumatic diseases | - |
dc.subject.keywordAuthor | Systolic pulmonary artery pressure | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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