Chemical Constituents from the Aerial Parts of Elsholtzia ciliata and Their Protective Activities on Glutamate-Induced HT22 Cell Death
DC Field | Value | Language |
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dc.contributor.author | Seo, Y.H. | - |
dc.contributor.author | Trinh, T.A. | - |
dc.contributor.author | Ryu, S.M. | - |
dc.contributor.author | Kim, H.S. | - |
dc.contributor.author | Choi, G. | - |
dc.contributor.author | Moon, B.C. | - |
dc.contributor.author | Shim, S.H. | - |
dc.contributor.author | Jang, D.S. | - |
dc.contributor.author | Lee, D. | - |
dc.contributor.author | Kang, K.S. | - |
dc.contributor.author | Lee, J. | - |
dc.date.available | 2020-12-23T00:40:10Z | - |
dc.date.created | 2020-11-03 | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/79390 | - |
dc.description.abstract | A new phenolic glucoside, (7E,9E)-3-hydroxyavenalumic acid-3-O-[6'-O-(E)-caffeoyl]-β-d-glucopyranoside (1), and three new acetylated flavone glycosides, acacetin-7-O-[β-d-glucopyranosyl(1″″→2″)-4‴-O-acetyl-α-l-rhamnopyranosyl(1‴→6″)]-β-d-glucopyranoside (3), acacetin-7-O-[6″″-O-acetyl-β-d-glucopyranosyl(1″″→2″)-3‴-O-acetyl-α-l-rhamnopyranosyl(1‴→6″)]-β-d-glucopyranoside (5), and acacetin-7-O-[3″″,6″″-di-O-acetyl-β-d-glucopyranosyl(1″″→2″)-4‴-O-acetyl-α-l-rhamnopyranosyl(1‴→6″)]-β-d-glucopyranoside (7), as well as 34 known compounds (2, 4, 6, and 8-38) were isolated from the aerial parts of Elsholtzia ciliata. The chemical structures of the new compounds were determined by spectroscopic/spectrometric data interpretation using NMR and HRESIMS. The neuroprotective effect of the isolated compounds was evaluated by a cell viability assay on HT22 murine hippocampal neuronal cells. Among them, 23 compounds, including new substances 1 and 3, exhibited neuroprotective effects against glutamate-induced HT22 cell death. In particular, compounds 2, 16, 17, 20, 22, 28, 29, and 31 presented potent neuroprotective effects with EC50 values of 1.5-8.3 μM. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | Journal of natural products | - |
dc.title | Chemical Constituents from the Aerial Parts of Elsholtzia ciliata and Their Protective Activities on Glutamate-Induced HT22 Cell Death | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000586023100034 | - |
dc.identifier.doi | 10.1021/acs.jnatprod.0c00756 | - |
dc.identifier.bibliographicCitation | Journal of natural products, v.83, no.10, pp.3149 - 3155 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85094219694 | - |
dc.citation.endPage | 3155 | - |
dc.citation.startPage | 3149 | - |
dc.citation.title | Journal of natural products | - |
dc.citation.volume | 83 | - |
dc.citation.number | 10 | - |
dc.contributor.affiliatedAuthor | Trinh, T.A. | - |
dc.contributor.affiliatedAuthor | Kang, K.S. | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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