The Prognostic Value of Serum Levels of Heart-Type Fatty Acid Binding Protein and High Sensitivity C-Reactive Protein in Patients With Increased Levels of Amino-Terminal Pro-B Type Natriuretic Peptide
DC Field | Value | Language |
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dc.contributor.author | Jeong, Ji Hun | - |
dc.contributor.author | Seo, Yiel Hea | - |
dc.contributor.author | Ahn, Jeong Yeal | - |
dc.contributor.author | Kim, Kyung Hee | - |
dc.contributor.author | Seo, Ja Young | - |
dc.contributor.author | Kim, Moon Jin | - |
dc.contributor.author | Lee, Hwan Tae | - |
dc.contributor.author | Park, Pil Whan | - |
dc.date.available | 2020-02-28T00:44:29Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2016-09 | - |
dc.identifier.issn | 2234-3806 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/7942 | - |
dc.description.abstract | Background: Amino-terminal pro-B type natriuretic peptide (NT-proBNP) is a well-established prognostic factor in heart failure (HF). However, numerous causes may lead to elevations in NT-proBNP, and thus, an increased NT-proBNP level alone is not sufficient to predict outcome. The aim of this study was to evaluate the utility of two acute response markers, high sensitivity C-reactive protein (hsCRP) and heart-type fatty acid binding protein (H-FABP), in patients with an increased NT-proBNP level. Methods: The 278 patients were classified into three groups by etiology: 1) acute coronary syndrome (ACS) (n=62), 2) non-ACS cardiac disease (n=156), and 3) infectious disease (n=60). Survival was determined on day 1, 7, 14, 21, 28, 60, 90, 120, and 150 after enrollment. Results: H-FABP (P<0.001), NT-proBNP (P=0.006), hsCRP (P<0.001) levels, and survival (P<0.001) were significantly different in the three disease groups. Patients were divided into three classes by using receiver operating characteristic curves for NT-proBNP, H-FABP, and hsCRP. Patients with elevated NT-proBNP (>= 3,856 pg/mL) and H-FABP (>= 8.8 ng/mL) levels were associated with higher hazard ratio for mortality (5.15 in NT-proBNP and 3.25 in H-FABP). Area under the receiver operating characteristic curve analysis showed H-FABP was a better predictor of 60-day mortality than NT-proBNP. Conclusions: The combined measurement of H-FABP with NT-proBNP provides a highly reliable means of short-term mortality prediction for patients hospitalized for ACS, non-ACS cardiac disease, or infectious disease. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC LABORATORY MEDICINE | - |
dc.relation.isPartOf | ANNALS OF LABORATORY MEDICINE | - |
dc.subject | ACUTE CORONARY SYNDROME | - |
dc.subject | ACUTE MYOCARDIAL-INFARCTION | - |
dc.subject | COMMUNITY-ACQUIRED PNEUMONIA | - |
dc.subject | H-FABP | - |
dc.subject | DIAGNOSIS | - |
dc.subject | BIOMARKERS | - |
dc.subject | RISK | - |
dc.subject | ACCURACY | - |
dc.subject | TROPONIN | - |
dc.subject | FAILURE | - |
dc.title | The Prognostic Value of Serum Levels of Heart-Type Fatty Acid Binding Protein and High Sensitivity C-Reactive Protein in Patients With Increased Levels of Amino-Terminal Pro-B Type Natriuretic Peptide | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000383471200004 | - |
dc.identifier.doi | 10.3343/alm.2016.36.5.420 | - |
dc.identifier.bibliographicCitation | ANNALS OF LABORATORY MEDICINE, v.36, no.5, pp.420 - 426 | - |
dc.identifier.kciid | ART002139274 | - |
dc.identifier.scopusid | 2-s2.0-84978225135 | - |
dc.citation.endPage | 426 | - |
dc.citation.startPage | 420 | - |
dc.citation.title | ANNALS OF LABORATORY MEDICINE | - |
dc.citation.volume | 36 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Jeong, Ji Hun | - |
dc.contributor.affiliatedAuthor | Seo, Yiel Hea | - |
dc.contributor.affiliatedAuthor | Ahn, Jeong Yeal | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Hee | - |
dc.contributor.affiliatedAuthor | Seo, Ja Young | - |
dc.contributor.affiliatedAuthor | Kim, Moon Jin | - |
dc.contributor.affiliatedAuthor | Lee, Hwan Tae | - |
dc.contributor.affiliatedAuthor | Park, Pil Whan | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Amino-terminal pro-B type natriuretic peptide | - |
dc.subject.keywordAuthor | Heart-type fatty acid binding protein | - |
dc.subject.keywordAuthor | High sensitivity C-reactive protein | - |
dc.subject.keywordAuthor | Prognostic marker | - |
dc.subject.keywordPlus | ACUTE CORONARY SYNDROME | - |
dc.subject.keywordPlus | ACUTE MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | COMMUNITY-ACQUIRED PNEUMONIA | - |
dc.subject.keywordPlus | H-FABP | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | BIOMARKERS | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | ACCURACY | - |
dc.subject.keywordPlus | TROPONIN | - |
dc.subject.keywordPlus | FAILURE | - |
dc.relation.journalResearchArea | Medical Laboratory Technology | - |
dc.relation.journalWebOfScienceCategory | Medical Laboratory Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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