C-Peptide Inhibits Decidualization in Human Endometrial Stromal Cells via GSK3β-PP1
DC Field | Value | Language |
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dc.contributor.author | Khaliq, S.A. | - |
dc.contributor.author | Baek, M.-O. | - |
dc.contributor.author | Cho, H.-J. | - |
dc.contributor.author | Chon, S.J. | - |
dc.contributor.author | Yoon, M.-S. | - |
dc.date.available | 2020-12-29T00:40:23Z | - |
dc.date.created | 2020-12-22 | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 2296-634X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/79466 | - |
dc.description.abstract | Decidualization refers to the functional differentiation of endometrial stromal cells and plays a significant role in embryo implantation and pregnancy. C-peptide is excreted in equimolar concentrations as that of insulin during the metabolism of proinsulin in pancreatic beta-cells. High levels of C-peptide are correlated with hyperinsulinemia and polycystic ovarian syndrome, which show a defect in decidualization. However, the role of C-peptide in decidualization has not yet been studied. Here, we identified C-peptide as an endogenous antideciduogenic factor. This inhibitory function was confirmed by the reduced expression of decidual markers, including prolactin, insulin-like growth factor-binding protein-1, and Forkhead box protein O1 as well as by the fibroblastic morphological change in the presence of C-peptide. C-peptide also enhanced cellular senescence and decreased the proportion of apoptotic cells during decidualization. In addition, C-peptide potentiated the inhibitory effects of both insulin and palmitic acid in an AKT- and autophagy-independent manner, respectively. Furthermore, C-peptide augmented protein phosphatase 1 (PP1) activity, leading to a reduction in the inhibitory phosphorylation of glycogen synthase kinase (GSK)3β, which resulted in enhanced cellular senescence and decreased apoptosis during decidualization. Taken together, our findings suggest that C-peptide is an antideciduogenic factor acting via the regulation between PP1 and GSK3β in patients with hyperinsulinemia. © Copyright © 2020 Khaliq, Baek, Cho, Chon and Yoon. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.relation.isPartOf | FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | - |
dc.title | C-Peptide Inhibits Decidualization in Human Endometrial Stromal Cells via GSK3β-PP1 | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000598155400001 | - |
dc.identifier.doi | 10.3389/fcell.2020.609551 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, v.8 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85097619150 | - |
dc.citation.title | FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | - |
dc.citation.volume | 8 | - |
dc.contributor.affiliatedAuthor | Khaliq, S.A. | - |
dc.contributor.affiliatedAuthor | Baek, M.-O. | - |
dc.contributor.affiliatedAuthor | Cho, H.-J. | - |
dc.contributor.affiliatedAuthor | Chon, S.J. | - |
dc.contributor.affiliatedAuthor | Yoon, M.-S. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | C-peptide | - |
dc.subject.keywordAuthor | decidualization | - |
dc.subject.keywordAuthor | GSK3 β | - |
dc.subject.keywordAuthor | PP1 | - |
dc.subject.keywordAuthor | senescence | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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