Chinese Hamster Lung 세포를 이용한 염색체이상 시험을 이용한 CP약침의 유전독성평가
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 황지혜 | - |
dc.contributor.author | 정철 | - |
dc.contributor.author | 구자승 | - |
dc.date.available | 2020-12-31T01:41:06Z | - |
dc.date.created | 2020-12-31 | - |
dc.date.issued | 2020-12 | - |
dc.identifier.issn | 1738-7698 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/79549 | - |
dc.description.abstract | This study was designed to assess the toxicity of capsaicin-containing (CP) pharmacopunture using an in vitro chromosomal aberrations in Chinese hamster lung (CHL/IU) cells. In order to determine the high dose level in the main study of this study, a dose range finding study was conducted first. The high dose was selected at 10.0% of CP pharmacopuncture extract, and then diluted sequentially to produce lower dose levels of 5.00, 2.50, 1.25, 0.625 and 0.313% by applying a geometric ratio of 2. As a result, the cytotoxicity and precipitation of the CP pharmacopuncture as a test substance were not evident at any dose level during short-time treatment with and without metabolic activation and continuous treatment without metabolic activation. Therefore, the dose levels for this study were chosen as 10.0, 5.0, and 2.5%., and the treatment volume was 1.3 mL. In addition, negative and positive controls were set. In main study, the frequency of cells with chromosome aberrations in CP treated groups was less than 5% in short-time treatment with and without metabolic activation and continuous treatment without metabolic activation. In addition, there was no statistically significant difference when compared to the negative control group. The frequency of cells with structural chromosomal aberrations in the positive control group was more than 10% compared to the negative control group, and it increased statistically significantly. In conclusion, under the conditions of this study, CP pharmacopuncture did not show the possibility of causing chromosome aberrations. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 한의병리학회 | - |
dc.relation.isPartOf | 동의생리병리학회지 | - |
dc.title | Chinese Hamster Lung 세포를 이용한 염색체이상 시험을 이용한 CP약침의 유전독성평가 | - |
dc.title.alternative | Evaluation of Genotoxicity of CP Pharmacopuncture Using an In Vitro Chromosome Aberration Test in Chinese Hamster Lung Cell | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.bibliographicCitation | 동의생리병리학회지, v.34, no.6, pp.355 - 361 | - |
dc.identifier.kciid | ART002661743 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 361 | - |
dc.citation.startPage | 355 | - |
dc.citation.title | 동의생리병리학회지 | - |
dc.citation.volume | 34 | - |
dc.citation.number | 6 | - |
dc.contributor.affiliatedAuthor | 황지혜 | - |
dc.subject.keywordAuthor | Chromosome Aberration Test | - |
dc.subject.keywordAuthor | Pharmacopuncture | - |
dc.subject.keywordAuthor | Safety | - |
dc.subject.keywordAuthor | CP | - |
dc.subject.keywordAuthor | Capsaicin | - |
dc.subject.keywordAuthor | Toxicity | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.