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Chemical constituents of Chaenomeles sinensis twigs and their biological activity
- Authors
- Cha, Joon Min; Kim, Dong Hyun; Subedi, Lalita; Khan, Zahra; Choi, Sang Un; Kim, Sun Yeou; Kim, Chung Sub
- Issue Date
- Dec-2020
- Publisher
- BEILSTEIN-INSTITUT
- Keywords
- antineuroinflammation; Chaenomeles sinensis; cytotoxicity; megastigmane; neurotrophic effect
- Citation
- BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, v.16, pp.3078 - 3085
- Journal Title
- BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
- Volume
- 16
- Start Page
- 3078
- End Page
- 3085
- ISSN
- 1860-5397
- Abstract
- A new megastigmane-type norsesquiterpenoid glycoside, chaemeloside (1), was isolated from the twigs of Chaenomeles sinensis together with 11 known phytochemicals through chromatographic methods. The chemical structure of the new isolate 1 was determined by conventional 1D and 2D NMR data analysis, ECD experiment, hydrolysis followed by a modified Mosher's method, and LC-MS analysis. The characterized compounds' biological effects including cytotoxicity against cancer cell lines, antineuroinflammatory activity, and potential neurotrophic effect were evaluated.
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Related Researcher
- Kim, Sun Yeou
- Pharmacy (Dept.of Pharmacy)