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All-trans Retinoic Acid Induces Expression and Secretion of Carboxypeptidase D in THP-1 Cells

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dc.contributor.authorHang Thi Thu Nguyen-
dc.contributor.author김재영-
dc.date.available2021-01-08T00:40:21Z-
dc.date.created2021-01-08-
dc.date.issued2020-12-
dc.identifier.issn1738-3226-
dc.identifier.urihttps://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/79661-
dc.description.abstractCarboxypeptidase D (CPD) is a zinc-dependent protease, which is highly expressed in macrophages, and is thought to participate in inflammatory processes. In the present study, we investigated the possible regulatory effect of all-trans retinoic acid (ATRA), which is an active form of vitamin A and plays a critical regulatory role in both the innate and adaptive immunity, on CPD expression and secretion in human monocytic THP-1 cells. CPD mRNA expression first increased, from a concentration as low as 10 nM ATRA to a maximum level of expression, at 1 μM. ATRA enhanced intracellular CPD expression in a time- and concentration-dependent manner but did not affect cell surface CPD expression. Interestingly, 9-cis-RA did not affect CPD expression. Additionally, an experiment with RAR/RXR selective agonist or antagonists demonstrated that ATRA-induced enhancement of CPD expression was RAR/RXR dependent. ATRA also enhanced CPD secretion from THP-1 cells; however, this enhancement was RAR/RXR-independent. The anti-inflammatory agent dexamethasone reversed ATRA-induced enhancement of CPD expression and secretion. Our results suggest ATRA exerts regulatory effects on expression and secretion of CPD in human monocytes, and ATRA-induced CPD secretion may be associated with inflammatory response.-
dc.language영어-
dc.language.isoen-
dc.publisher대한의생명과학회-
dc.relation.isPartOf대한의생명과학회지-
dc.titleAll-trans Retinoic Acid Induces Expression and Secretion of Carboxypeptidase D in THP-1 Cells-
dc.title.alternativeAll-trans Retinoic Acid Induces Expression and Secretion of Carboxypeptidase D in THP-1 Cells-
dc.typeArticle-
dc.type.rimsART-
dc.description.journalClass2-
dc.identifier.bibliographicCitation대한의생명과학회지, v.26, no.4, pp.256 - 266-
dc.identifier.kciidART002673771-
dc.description.isOpenAccessN-
dc.citation.endPage266-
dc.citation.startPage256-
dc.citation.title대한의생명과학회지-
dc.citation.volume26-
dc.citation.number4-
dc.contributor.affiliatedAuthorHang Thi Thu Nguyen-
dc.contributor.affiliatedAuthor김재영-
dc.subject.keywordAuthorAll-trans retinoic acid-
dc.subject.keywordAuthorCarboxypeptidase D-
dc.subject.keywordAuthorTHP-1-
dc.subject.keywordAuthorMonocytes-
dc.subject.keywordAuthorVitamin A-
dc.subject.keywordAuthorSecretion-
dc.subject.keywordAuthorInflammation-
dc.description.journalRegisteredClasskci-
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