Neurotrophic isoindolinones from the fruiting bodies of Hericium erinaceus
DC Field | Value | Language |
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dc.contributor.author | Ryu, Se Hwan | - |
dc.contributor.author | Hong, Seong Min | - |
dc.contributor.author | Khan, Zahra | - |
dc.contributor.author | Lee, Seul Ki | - |
dc.contributor.author | Vishwanath, Manjunatha | - |
dc.contributor.author | Turk, Ayman | - |
dc.contributor.author | Yeon, Sang Won | - |
dc.contributor.author | Jo, Yang Hee | - |
dc.contributor.author | Lee, Dae Hee | - |
dc.contributor.author | Lee, Jae Kang | - |
dc.contributor.author | Hwang, Bang Yeon | - |
dc.contributor.author | Jung, Jae-Kyung | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Lee, Mi Kyeong | - |
dc.date.available | 2021-01-13T01:40:22Z | - |
dc.date.created | 2021-01-13 | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/79697 | - |
dc.description.abstract | Four compounds, hericerin (1), isohericerinol A (2), N-de-phenylethyl isohericerin (3) and corallocin A (4) were isolated from the fruiting bodies of Hericium erinaceus, a lion's mane mushroom (Hericiaceae). Among them, isohericerinol A (2) was newly reported in nature. Further investigation of the neurotrophic effect of isolated compounds demonstrated that isohericerinol A (2) strongly increased the nerve growth factor (NGF) production in C6 glioma cells followed by corallocin A (4) and hericerin (1). Increased NGF production by these compounds promoted the neurite outgrowth in N2a neuronal cells. Western blot analysis also showed the increased protein expression of NGF, brain-derived neurotrophic factor (BDNF) and synaptophysin (SYP) in C6-N2a cells. Taken together, our present study characterized the neurotrophic constituents of H. erinaceus, which may support the potential use of memory improvement. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.title | Neurotrophic isoindolinones from the fruiting bodies of Hericium erinaceus | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000602366100006 | - |
dc.identifier.doi | 10.1016/j.bmcl.2020.127714 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.31 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85096894560 | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.volume | 31 | - |
dc.contributor.affiliatedAuthor | Hong, Seong Min | - |
dc.contributor.affiliatedAuthor | Khan, Zahra | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Hericium erinaceus | - |
dc.subject.keywordAuthor | Hericiaceae | - |
dc.subject.keywordAuthor | Isoindolinone | - |
dc.subject.keywordAuthor | Neurotrophic factor | - |
dc.subject.keywordAuthor | Neurite outgrowth | - |
dc.subject.keywordAuthor | Isohericerinol A | - |
dc.subject.keywordPlus | LIONS MANE MUSHROOM | - |
dc.subject.keywordPlus | BIOLOGICAL-ACTIVITIES | - |
dc.subject.keywordPlus | AROMATIC-COMPOUNDS | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | MYCELIA | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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