Gamma-aminobutyric acid-salt attenuated high cholesterol/high salt diet induced hypertension in mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 손명주 | - |
dc.contributor.author | 오세연 | - |
dc.contributor.author | 이혜선 | - |
dc.contributor.author | Junwon Choi | - |
dc.contributor.author | 이배진 | - |
dc.contributor.author | Joung-Hyun Park | - |
dc.contributor.author | 박철현 | - |
dc.contributor.author | 손국희 | - |
dc.contributor.author | 변경희 | - |
dc.date.available | 2021-01-13T05:40:24Z | - |
dc.date.created | 2020-12-31 | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/79707 | - |
dc.description.abstract | Excessive salt intake induces hypertension, but several gamma-aminobutyric acid (GABA) supplements have been shown to reduce blood pressure. GABAsalt, a fermented salt by L. brevis BJ20 containing GABA was prepared through the post-fermentation with refined salt and the fermented GABA extract. We evaluated the effect of GABA-salt on hypertension in a high salt, high cholesterol diet induced mouse model. We analyzed type 1 macrophage (M1) polarization, the expression of M1 related cytokines, GABA receptor expression, endothelial cell (EC) dysfunction, vascular smooth muscle cell (VSMC) proliferation, and medial thicknesses in mice model. GABA-salt attenuated diet-induced blood pressure increases, M1 polarization, and TNF-α and inducible nitric oxide synthase (NOS) levels in mouse aortas, and in salt treated macrophages in vitro. Furthermore, GABA-salt induced higher GABAB receptor and endothelial NOS (eNOS) and eNOS phosphorylation levels than those observed in salt treated ECs. In addition, GABA-salt attenuated EC dysfunction by decreasing the levels of adhesion molecules (E-selectin, Intercellular Adhesion Molecule- 1 [ICAM-1], vascular cell adhesion molecule-1 [VCAM-1]) and of von Willebrand Factor and reduced EC death. GABA-salt also reduced diet-induced reductions in the levels of eNOS, phosphorylated eNOS, VSMC proliferation and medial thickening in mouse aortic tissues, and attenuated Endothelin-1 levels in salt treated VSMCs. In summary, GABA-salt reduced high salt, high cholesterol diet induced hypertension in our mouse model by reducing M1 polarization, EC dysfunction, and VSMC proliferation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한약리학회 | - |
dc.relation.isPartOf | The Korean Journal of Physiology & Pharmacology | - |
dc.title | Gamma-aminobutyric acid-salt attenuated high cholesterol/high salt diet induced hypertension in mice | - |
dc.title.alternative | Gamma-aminobutyric acid-salt attenuated high cholesterol/high salt diet induced hypertension in mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000602986300003 | - |
dc.identifier.doi | 10.4196/kjpp.2021.25.1.27 | - |
dc.identifier.bibliographicCitation | The Korean Journal of Physiology & Pharmacology, v.25, no.1, pp.27 - 38 | - |
dc.identifier.kciid | ART002663071 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85099797753 | - |
dc.citation.endPage | 38 | - |
dc.citation.startPage | 27 | - |
dc.citation.title | The Korean Journal of Physiology & Pharmacology | - |
dc.citation.volume | 25 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | 손명주 | - |
dc.contributor.affiliatedAuthor | 오세연 | - |
dc.contributor.affiliatedAuthor | 이혜선 | - |
dc.contributor.affiliatedAuthor | Junwon Choi | - |
dc.contributor.affiliatedAuthor | 박철현 | - |
dc.contributor.affiliatedAuthor | 손국희 | - |
dc.contributor.affiliatedAuthor | 변경희 | - |
dc.subject.keywordAuthor | Blood pressure | - |
dc.subject.keywordAuthor | Endothelial cells | - |
dc.subject.keywordAuthor | Gamma-aminobutyric acid (GABA)-salt | - |
dc.subject.keywordAuthor | Macrophage polarization | - |
dc.subject.keywordAuthor | Smooth muscle cells | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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