Essential Amino Acids and Protein Synthesis: Insights into Maximizing the Muscle and Whole-Body Response to Feeding
DC Field | Value | Language |
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dc.contributor.author | Church, D.D. | - |
dc.contributor.author | Hirsch, K.R. | - |
dc.contributor.author | Park, Sanghee | - |
dc.contributor.author | Kim, Il-Young | - |
dc.contributor.author | Gwin, J.A. | - |
dc.contributor.author | Pasiakos, S.M. | - |
dc.contributor.author | Wolfe, R.R. | - |
dc.contributor.author | Ferrando, A.A. | - |
dc.date.available | 2021-01-13T05:41:09Z | - |
dc.date.created | 2020-12-15 | - |
dc.date.issued | 2020-12 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/79719 | - |
dc.description.abstract | Ingesting protein-containing supplements and foods provides essential amino acids (EAA) necessary to increase muscle and whole-body protein synthesis (WBPS). Large variations exist in the EAA composition of supplements and foods, ranging from free-form amino acids to whole protein foods. We sought to investigate how changes in peripheral EAA after ingesting various protein and free amino acid formats altered muscle and whole-body protein synthesis. Data were compiled from four previous studies that used primed, constant infusions of L-(ring-2 H5)-phenylalanine and L-(3,3-2 H2 )-tyrosine to determine fractional synthetic rate of muscle protein (FSR), WBPS, and circulating EAA concentrations. Stepwise regression indicated that max EAA concentration (EAACmax; R2 = 0.524, p < 0.001), EAACmax (R2 = 0.341, p < 0.001), and change in EAA concentration (∆EAA; R = 0.345, p < 0.001) were the strongest predictors for postprandial FSR, ∆ (change from post absorptive to postprandial) FSR, and ∆WBPS, respectively. Within our dataset, the stepwise regression equation indicated that a 100% increase in peripheral EAA concentrations increases FSR by ~34%. Further, we observed significant (p < 0.05) positive (R = 0.420–0.724) correlations between the plasma EAA area under the curve above baseline, EAACmax, ∆EAA, and rate to EAACmax to postprandial FSR, ∆FSR, and ∆WBPS. Taken together our results indicate that across a large variety of EAA/protein-containing formats and food, large increases in peripheral EAA concentrations are required to drive a robust increase in muscle and whole-body protein synthesis. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | NUTRIENTS | - |
dc.title | Essential Amino Acids and Protein Synthesis: Insights into Maximizing the Muscle and Whole-Body Response to Feeding | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000602617200001 | - |
dc.identifier.doi | 10.3390/nu12123717 | - |
dc.identifier.bibliographicCitation | NUTRIENTS, v.12, no.12, pp.1 - 14 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85097222650 | - |
dc.citation.endPage | 14 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | NUTRIENTS | - |
dc.citation.volume | 12 | - |
dc.citation.number | 12 | - |
dc.contributor.affiliatedAuthor | Park, Sanghee | - |
dc.contributor.affiliatedAuthor | Kim, Il-Young | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Aging | - |
dc.subject.keywordAuthor | Amino acid kinetics | - |
dc.subject.keywordAuthor | Anabolism | - |
dc.subject.keywordAuthor | Essential amino acids | - |
dc.subject.keywordAuthor | Muscle protein synthesis | - |
dc.subject.keywordAuthor | Nutrition | - |
dc.subject.keywordAuthor | Protein | - |
dc.subject.keywordAuthor | Protein quality | - |
dc.subject.keywordAuthor | Whole body protein synthesis | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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