The tacrolimus metabolism affect post-transplant outcome mediating acute rejection and delayed graft function: analysis from Korean Organ Transplantation Registry data
DC Field | Value | Language |
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dc.contributor.author | Ro, Han | - |
dc.contributor.author | Jeong, Jong Cheol | - |
dc.contributor.author | Kong, Jin Min | - |
dc.contributor.author | Min, Ji Won | - |
dc.contributor.author | Park, Sung Kwang | - |
dc.contributor.author | Lee, Joongyub | - |
dc.contributor.author | Koo, Tai Yeon | - |
dc.contributor.author | Yang, Jaeseok | - |
dc.contributor.author | Kim, Myoung Soo | - |
dc.contributor.author | Hwang, Seungsik | - |
dc.contributor.author | Ahn, Curie | - |
dc.date.available | 2021-01-20T00:40:10Z | - |
dc.date.created | 2020-11-23 | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 0934-0874 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/79779 | - |
dc.description.abstract | Tacrolimus is a key drug in kidney transplantation (KT) with a narrow therapeutic index. The association between the tacrolimus metabolism rate and KT outcomes have not been investigated in large-scale multi-center studies. The Korean Organ Transplantation Registry (KOTRY) datasets were used. A total of 3456 KT recipients were analyzed. The tacrolimus metabolism rate was defined as blood trough concentration of tacrolimus (C-0) divided by the daily dose (D). The patients were grouped into fast, intermediate, or slow metabolizers by the C-0/D measured 6 months after transplantation. The slow metabolism group was associated with a 2.7 ml/min/1.73 m(2) higher adjusted estimated glomerular filtration rate (eGFR) at 6 months [95% confidence interval (C.I.) 1.2-4.3, P = 0.001], less acute rejection (AR) within 6 months [Odds ratio (OR) 0.744, 95% C.I. 0.585-0.947, P = 0.016], and less interstitial fibrosis and tubular atrophy [OR 0.606, 95% C.I. 0.390-0.940, P = 0.025]. Fast tacrolimus metabolism affected the 6-month post-KT eGFR through mediation of AR [natural indirect effect (NIE) -0.434, 95% C.I. -0.856 to -0.012, P = 0.044) and delayed graft function (DGF; NIE -0.119, 95% C.I. -0.231 to -0.007, P = 0.038). Slow tacrolimus metabolism was associated with better post-KT eGFR. AR and DGF were found to be significant mediators. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.relation.isPartOf | TRANSPLANT INTERNATIONAL | - |
dc.title | The tacrolimus metabolism affect post-transplant outcome mediating acute rejection and delayed graft function: analysis from Korean Organ Transplantation Registry data | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000587373800001 | - |
dc.identifier.doi | 10.1111/tri.13777 | - |
dc.identifier.bibliographicCitation | TRANSPLANT INTERNATIONAL, v.34, no.1, pp.163 - 174 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85096721581 | - |
dc.citation.endPage | 174 | - |
dc.citation.startPage | 163 | - |
dc.citation.title | TRANSPLANT INTERNATIONAL | - |
dc.citation.volume | 34 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Ro, Han | - |
dc.type.docType | Article; Early Access | - |
dc.subject.keywordAuthor | kidney transplantation | - |
dc.subject.keywordAuthor | pharmacogenetics | - |
dc.subject.keywordAuthor | tacrolimus metabolism | - |
dc.subject.keywordPlus | CYP3A5 GENOTYPE | - |
dc.subject.keywordPlus | TROUGH LEVELS | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | POLYMORPHISMS | - |
dc.subject.keywordPlus | VARIABILITY | - |
dc.subject.keywordPlus | ADHERENCE | - |
dc.subject.keywordPlus | PATTERNS | - |
dc.subject.keywordPlus | EXPOSURE | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | IMPACT | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalResearchArea | Transplantation | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.relation.journalWebOfScienceCategory | Transplantation | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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