Structure-Activity Relationship of Phytoestrogen Analogs as ER alpha/beta Agonists with Neuroprotective Activities
DC Field | Value | Language |
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dc.contributor.author | Cho, H.W. | - |
dc.contributor.author | Gim, H.J. | - |
dc.contributor.author | Li, H. | - |
dc.contributor.author | Subedi, L. | - |
dc.contributor.author | Kim, S.Y. | - |
dc.contributor.author | Ryu, J.-H. | - |
dc.contributor.author | Jeon, R. | - |
dc.date.available | 2021-01-25T00:40:21Z | - |
dc.date.created | 2021-01-20 | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 0009-2363 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/79805 | - |
dc.description.abstract | A set of isoflavononid and flavonoid analogs was prepared and evaluated for estrogen receptor α (ERα) and ERβ transactivation and anti-neuroinflammatory activities. Structure–activity relationship (SAR) study of naturally occurring phytoestrogens, their metabolites, and related isoflavone analogs revealed the importance of the C-ring of isoflavonoids for ER activity and selectivity. Docking study suggested putative binding modes of daidzein 2 and dehydroequol 8 in the active site of ERα and ERβ, and provided an understanding of the promising activity and selectivity of dehydroequol 8. Among the tested compounds, equol 7 and dehydroequol 8 were the most potent ERα/β agonists with ERβ selectivity and neuroprotective activity. This study provides knowledge on the SAR of isoflavonoids for further development of potent and selective ER agonists with neuroprotective potential. © 2021 The Pharmaceutical Society of Japan | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Pharmaceutical Society of Japan | - |
dc.relation.isPartOf | Chemical and Pharmaceutical Bulletin | - |
dc.title | Structure-Activity Relationship of Phytoestrogen Analogs as ER alpha/beta Agonists with Neuroprotective Activities | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000604910700016 | - |
dc.identifier.doi | 10.1248/cpb.c20-00706 | - |
dc.identifier.bibliographicCitation | Chemical and Pharmaceutical Bulletin, v.69, no.1, pp.99 - 105 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85098658648 | - |
dc.citation.endPage | 105 | - |
dc.citation.startPage | 99 | - |
dc.citation.title | Chemical and Pharmaceutical Bulletin | - |
dc.citation.volume | 69 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Subedi, L. | - |
dc.contributor.affiliatedAuthor | Kim, S.Y. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Anti-neuroinflammation | - |
dc.subject.keywordAuthor | Estrogen receptor agonist | - |
dc.subject.keywordAuthor | Phytoestrogen | - |
dc.subject.keywordAuthor | Structure–activity relationship | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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