Region-specific amyloid-β accumulation in the olfactory system influences olfactory sensory neuronal dysfunction in 5xFAD mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Son, Gowoon | - |
dc.contributor.author | Yoo, Seung-Jun | - |
dc.contributor.author | Kang, Shinwoo | - |
dc.contributor.author | Rasheed, Ameer | - |
dc.contributor.author | Jung, Da Hae | - |
dc.contributor.author | Park, Hyunjun | - |
dc.contributor.author | Cho, Bongki | - |
dc.contributor.author | Steinbusch, H.W.M. | - |
dc.contributor.author | Chang, Keun-A | - |
dc.contributor.author | Suh, Yoo-Hun | - |
dc.contributor.author | Moon, Cheil | - |
dc.date.available | 2021-01-29T07:40:10Z | - |
dc.date.created | 2021-01-20 | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 1758-9193 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/79843 | - |
dc.description.abstract | Background: Hyposmia in Alzheimer’s disease (AD) is a typical early symptom according to numerous previous clinical studies. Although amyloid-β (Aβ), which is one of the toxic factors upregulated early in AD, has been identified in many studies, even in the peripheral areas of the olfactory system, the pathology involving olfactory sensory neurons (OSNs) remains poorly understood. Methods: Here, we focused on peripheral olfactory sensory neurons (OSNs) and delved deeper into the direct relationship between pathophysiological and behavioral results using odorants. We also confirmed histologically the pathological changes in 3-month-old 5xFAD mouse models, which recapitulates AD pathology. We introduced a numeric scale histologically to compare physiological phenomenon and local tissue lesions regardless of the anatomical plane. Results: We observed the odorant group that the 5xFAD mice showed reduced responses to odorants. These also did not physiologically activate OSNs that propagate their axons to the ventral olfactory bulb. Interestingly, the amount of accumulated amyloid-β (Aβ) was high in the OSNs located in the olfactory epithelial ectoturbinate and the ventral olfactory bulb glomeruli. We also observed irreversible damage to the ectoturbinate of the olfactory epithelium by measuring the impaired neuronal turnover ratio from the basal cells to the matured OSNs. Conclusions: Our results showed that partial and asymmetrical accumulation of Aβ coincided with physiologically and structurally damaged areas in the peripheral olfactory system, which evoked hyporeactivity to some odorants. Taken together, partial olfactory dysfunction closely associated with peripheral OSN’s loss could be a leading cause of AD-related hyposmia, a characteristic of early AD. © 2021, The Author(s). | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.relation.isPartOf | ALZHEIMERS RESEARCH & THERAPY | - |
dc.title | Region-specific amyloid-β accumulation in the olfactory system influences olfactory sensory neuronal dysfunction in 5xFAD mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000607073200004 | - |
dc.identifier.doi | 10.1186/s13195-020-00730-2 | - |
dc.identifier.bibliographicCitation | ALZHEIMERS RESEARCH & THERAPY, v.13, no.1 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85098671331 | - |
dc.citation.title | ALZHEIMERS RESEARCH & THERAPY | - |
dc.citation.volume | 13 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Kang, Shinwoo | - |
dc.contributor.affiliatedAuthor | Park, Hyunjun | - |
dc.contributor.affiliatedAuthor | Chang, Keun-A | - |
dc.contributor.affiliatedAuthor | Suh, Yoo-Hun | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | 5xFAD | - |
dc.subject.keywordAuthor | Alzheimer’s disease | - |
dc.subject.keywordAuthor | Ca2+ imaging | - |
dc.subject.keywordAuthor | Neuronal turnover | - |
dc.subject.keywordAuthor | Odor detection test | - |
dc.subject.keywordAuthor | Olfactory dysfunction | - |
dc.subject.keywordAuthor | Olfactory sensory neuron | - |
dc.subject.keywordAuthor | Topographic analysis | - |
dc.subject.keywordAuthor | Zonal organization | - |
dc.subject.keywordAuthor | β-amyloid | - |
dc.subject.keywordPlus | amyloid beta protein | - |
dc.subject.keywordPlus | 5xFAD mouse | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | Alzheimer disease | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal model | - |
dc.subject.keywordPlus | animal tissue | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | axon | - |
dc.subject.keywordPlus | basal cell | - |
dc.subject.keywordPlus | bioaccumulation | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | hyposmia | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | mouse | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | odor | - |
dc.subject.keywordPlus | olfactory bulb | - |
dc.subject.keywordPlus | olfactory discrimination | - |
dc.subject.keywordPlus | olfactory epithelium | - |
dc.subject.keywordPlus | olfactory receptor neuron | - |
dc.subject.keywordPlus | olfactory system | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | turbinate | - |
dc.subject.keywordPlus | turnover rate | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.