Treadmill exercise in obese maternal rats during pregnancy improves spatial memory through activation of phosphatidylinositol 3-kinase pathway in the hippocampus of rat pups
DC Field | Value | Language |
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dc.contributor.author | 고영준 | - |
dc.contributor.author | 김보균 | - |
dc.contributor.author | 지은상 | - |
dc.date.available | 2021-02-03T23:40:32Z | - |
dc.date.created | 2021-01-04 | - |
dc.date.issued | 2020-12 | - |
dc.identifier.issn | 2288-176X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/79892 | - |
dc.description.abstract | Maternal nutrition is necessary for the growth of the fetus, and excessive intake of nutrients interferes with brain development in offspring. In the current study, the effect of treadmill running during pregnancy in obese maternal rats on spatial learning memory and spatial working memory in rat pups was investigated. Phosphorylation of phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt), and extracellular signal-regulated kinase 1 and 2 (ERK1/2) was also identified in rat pups. Female rats were divided into the normal diet group and the high-fat diet group for 7 weeks, including pregnancy and lactation. Maternal treadmill running was performed for 4 weeks. The born rat pups were classified into a control group, a treadmill exercise group, a high-fat diet group, a high-fat diet and treadmill exercise group according to the status of maternal rats. Radial 8-arm maze task for spatial learning memory and Morris water maze task for spatial working memory were done. Western blot analysis was conducted to determine the expressions of PI3K, Akt, ERK1/2. In the current results, maternal treadmill running during pregnancy improved spatial learning memory and spatial working memory in rat pups born to obese maternal rats. This improving effect of memory was due to the enhanced phosphorylation of PI3K, Akt, and ERK1/2 by treadmill running. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 한국운동재활학회 | - |
dc.relation.isPartOf | Journal of exercise rehabilitation | - |
dc.title | Treadmill exercise in obese maternal rats during pregnancy improves spatial memory through activation of phosphatidylinositol 3-kinase pathway in the hippocampus of rat pups | - |
dc.title.alternative | Treadmill exercise in obese maternal rats during pregnancy improves spatial memory through activation of phosphatidylinositol 3-kinase pathway in the hippocampus of rat pups | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000604551400003 | - |
dc.identifier.doi | 10.12965/jer.2040822.411 | - |
dc.identifier.bibliographicCitation | Journal of exercise rehabilitation, v.16, no.6, pp.483 - 488 | - |
dc.identifier.kciid | ART002668574 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85099926036 | - |
dc.citation.endPage | 488 | - |
dc.citation.startPage | 483 | - |
dc.citation.title | Journal of exercise rehabilitation | - |
dc.citation.volume | 16 | - |
dc.citation.number | 6 | - |
dc.contributor.affiliatedAuthor | 김보균 | - |
dc.subject.keywordAuthor | Maternal obesity | - |
dc.subject.keywordAuthor | Pregnancy | - |
dc.subject.keywordAuthor | Treadmill exercise | - |
dc.subject.keywordAuthor | PI3K | - |
dc.subject.keywordAuthor | Rat pups | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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