Porous Platinum Black-Coated Minimally Invasive Microneedles for Non-Enzymatic Continuous Glucose Monitoring in Interstitial Fluid
DC Field | Value | Language |
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dc.contributor.author | Chinnadayyala, S.R. | - |
dc.contributor.author | Cho, Sungbo | - |
dc.date.available | 2021-02-16T02:40:24Z | - |
dc.date.created | 2021-01-20 | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 2079-4991 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/79970 | - |
dc.description.abstract | Individuals with diabetes can benefit considerably from continuous blood glucose moni-toring. To address this challenge, a proof-of-concept was performed for continuous glucose monitoring (CGM) based on an enzymeless porous nanomaterial (pNM)-modified microneedle electrode array (MNEA). The pNM sensing layer was electrochemically deposited on MNs by applying a fixed negative current of −2.5 mAcm˗2 for 400 s. The pNM-modified MNEA was packed using a biocompatible Nafion ionomer. The fabricated MNEAs were 600 × 100 × 150 µm in height, width, and thickness, respectively. The surfaces of the modified MNs were characterized by scanning electron microscopy (SEM) and energy dispersive X-ray analysis (EDX), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). The fabricated MNEAs showed a wide dynamic range (1–30 mM) in phosphate-buffered saline (PBS) and in artificial interstitial fluid (ISF), with good sensitivi-ties (PBS: 1.792 ± 0.25 µA mM−1 cm−2, ISF: 0.957 ± 0.14 µA mM−1 cm−2) and low detection limits (PBS: 7.2 µM, ISF: 22 µM). The sensor also showed high stability (loss of 3.5% at the end of 16 days), selectivity, and reproducibility (Relative standard deviations (RSD) of 1.64% and 0.70% for intra-and inter-assay, respectively) and a good response time (2 s) with great glucose recovery rates in ISF (98.7–102%). © 2020 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | NANOMATERIALS | - |
dc.title | Porous Platinum Black-Coated Minimally Invasive Microneedles for Non-Enzymatic Continuous Glucose Monitoring in Interstitial Fluid | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000610663100001 | - |
dc.identifier.doi | 10.3390/nano11010037 | - |
dc.identifier.bibliographicCitation | NANOMATERIALS, v.11, no.1, pp.1 - 15 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85098708014 | - |
dc.citation.endPage | 15 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | NANOMATERIALS | - |
dc.citation.volume | 11 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Chinnadayyala, S.R. | - |
dc.contributor.affiliatedAuthor | Cho, Sungbo | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Chronoamperometry | - |
dc.subject.keywordAuthor | Cyclic voltammetry | - |
dc.subject.keywordAuthor | Electrodeposition | - |
dc.subject.keywordAuthor | Glucose sensor | - |
dc.subject.keywordAuthor | Microneedle electrode array | - |
dc.subject.keywordAuthor | Platinum black | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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