Emerging roles of non-coding RNAs in the response of rectal cancer to radiotherapy (Review)
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Thi, Huyen Trang Ha | - |
dc.contributor.author | Duong, Hong-Quan | - |
dc.contributor.author | Hong, Suntaek | - |
dc.date.available | 2021-02-25T00:40:13Z | - |
dc.date.created | 2021-02-25 | - |
dc.date.issued | 2021-03 | - |
dc.identifier.issn | 1019-6439 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/80014 | - |
dc.description.abstract | Radiotherapy (RT) followed by radical surgery is an effective standard treatment strategy for various types of cancer, including rectal cancer. The response to RT varies among patients, and the radiosensitivity of cancer cells determines the clinical outcome of patients. However, the application of RT to patients with radioresistant tumors may result in radiation-induced toxicity without clinical benefits. Currently, there are no effective methods to predict the response to RT. The limitations of the methods currently used to evaluate tumor radiosensitivity, which are mainly based on clinical and radiological features, are low sensitivity and specificity. Non-coding RNAs (ncRNAs) have emerged as a class of biomarkers for predicting radiosensitivity. In particular, the expression pattern of ncRNAs can predict the response to RT in patients with rectal cancer. Thus, ncRNAs may be used as potential biomarkers and therapeutic targets to improve the diagnosis and treatment outcome of patients with rectal cancer. In the present review, the current knowledge on the limitations of RT for rectal cancer and the association between ncRNA expression and sensitivity of rectal cancer to RT are presented. Additionally, the potential of ncRNAs as predictive biomarkers and therapeutic targets to mitigate resistance of rectal cancer to RT is discussed. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.language.iso | en | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF ONCOLOGY | - |
dc.title | Emerging roles of non-coding RNAs in the response of rectal cancer to radiotherapy (Review) | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000615937600001 | - |
dc.identifier.doi | 10.3892/ijo.2021.5175 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF ONCOLOGY, v.58, no.3, pp.344 - 358 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85101006110 | - |
dc.citation.endPage | 358 | - |
dc.citation.startPage | 344 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF ONCOLOGY | - |
dc.citation.volume | 58 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Hong, Suntaek | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | radiotherapy | - |
dc.subject.keywordAuthor | rectal cancer | - |
dc.subject.keywordAuthor | non-coding RNA | - |
dc.subject.keywordAuthor | predictive biomarker | - |
dc.subject.keywordAuthor | radioresistance | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.