Betacellulin-Induced α-Cell Proliferation Is Mediated by ErbB3 and ErbB4, and May Contribute to β-Cell Regeneration
DC Field | Value | Language |
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dc.contributor.author | Lee, Young-Sun | - |
dc.contributor.author | Song, Gyun Jee | - |
dc.contributor.author | Jun, Hee-Sook | - |
dc.date.available | 2021-02-25T00:40:20Z | - |
dc.date.created | 2021-02-16 | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 2296-634X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/80016 | - |
dc.description.abstract | Betacellulin (BTC), an epidermal growth factor family, is known to promote β-cell regeneration. Recently, pancreatic α-cells have been highlighted as a source of new β-cells. We investigated the effect of BTC on α-cells. Insulin+glucagon+ double stained bihormonal cell levels and pancreatic and duodenal homeobox-1 expression were increased in mice treated with recombinant adenovirus-expressing BTC (rAd-BTC) and β-cell-ablated islet cells treated with BTC. In the islets of rAd-BTC-treated mice, both BrdU+glucagon+ and BrdU+insulin+ cell levels were significantly increased, with BrdU+glucagon+ cells showing the greater increase. Treatment of αTC1-9 cells with BTC significantly increased proliferation and cyclin D2 expression. BTC induced phosphorylation of ErbB receptors in αTC1-9 cells. The proliferative effect of BTC was mediated by ErbB-3 or ErbB-4 receptor kinase. BTC increased phosphorylation of ERK1/2, AKT, and mTOR and PC1/3 expression and GLP-1 production in α-cells, but BTC-induced proliferation was not changed by the GLP-1 receptor antagonist, exendin-9. We suggest that BTC has a direct role in α-cell proliferation via interaction with ErbB-3 and ErbB-4 receptors, and these increased α-cells might be a source of new β-cells. © Copyright © 2021 Lee, Song and Jun. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Frontiers Media S.A. | - |
dc.relation.isPartOf | Frontiers in Cell and Developmental Biology | - |
dc.title | Betacellulin-Induced α-Cell Proliferation Is Mediated by ErbB3 and ErbB4, and May Contribute to β-Cell Regeneration | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000614388800001 | - |
dc.identifier.doi | 10.3389/fcell.2020.605110 | - |
dc.identifier.bibliographicCitation | Frontiers in Cell and Developmental Biology, v.8 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85100451449 | - |
dc.citation.title | Frontiers in Cell and Developmental Biology | - |
dc.citation.volume | 8 | - |
dc.contributor.affiliatedAuthor | Lee, Young-Sun | - |
dc.contributor.affiliatedAuthor | Jun, Hee-Sook | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | betacellulin | - |
dc.subject.keywordAuthor | ErbB receptor | - |
dc.subject.keywordAuthor | pancreatic α-cell | - |
dc.subject.keywordAuthor | pancreatic β-cell | - |
dc.subject.keywordAuthor | regeneration | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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