Pontin arginine methylation by CARM1 is crucial for epigenetic regulation of autophagy
DC Field | Value | Language |
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dc.contributor.author | Yu, Young Suk | - |
dc.contributor.author | Shin, Hijai R. | - |
dc.contributor.author | Kim, Dongha | - |
dc.contributor.author | Baek, Seon Ah | - |
dc.contributor.author | Choi, Seon Ah | - |
dc.contributor.author | Ahn, Hyejin | - |
dc.contributor.author | Shamim, Amen | - |
dc.contributor.author | Kim, Jeonghwan | - |
dc.contributor.author | Kim, Ik Soo | - |
dc.contributor.author | Kim, Kyeong Kyu | - |
dc.contributor.author | Won, Kyoung-Jae | - |
dc.contributor.author | Baek, Sung Hee | - |
dc.date.available | 2021-02-26T07:40:03Z | - |
dc.date.created | 2021-02-26 | - |
dc.date.issued | 2020-12 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/80076 | - |
dc.description.abstract | Autophagy is a catabolic process through which cytoplasmic components are degraded and recycled in response to various stresses including starvation. Recently, transcriptional and epigenetic regulations of autophagy have emerged as essential mechanisms for maintaining homeostasis. Here, we identify that coactivator-associated arginine methyltransferase 1 (CARM1) methylates Pontin chromatin-remodeling factor under glucose starvation, and methylated Pontin binds Forkhead Box O 3a (FOXO3a). Genome-wide analyses and biochemical studies reveal that methylated Pontin functions as a platform for recruiting Tip60 histone acetyltransferase with increased H4 acetylation and subsequent activation of autophagy genes regulated by FOXO3a. Surprisingly, CARM1-Pontin-FOXO3a signaling axis can work in the distal regions and activate autophagy genes through enhancer activation. Together, our findings provide a signaling axis of CARM1-Pontin-FOXO3a and further expand the role of CARM1 in nuclear regulation of autophagy. Epigenetic regulations of autophagy have emerged as mechanisms for maintaining cellular homeostasis. Here the authors reveal that the CARM1-Pontin-FOXO3a signaling axis can activate autophagy related genes through enhancer activation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE RESEARCH | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.title | Pontin arginine methylation by CARM1 is crucial for epigenetic regulation of autophagy | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000608838700005 | - |
dc.identifier.doi | 10.1038/s41467-020-20080-9 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.11, no.1 | - |
dc.description.isOpenAccess | N | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 11 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Kim, Ik Soo | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL REGULATION | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | TIP60 | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | BIOLOGY | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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