Antioxidant and cognitive-enhancing activities of Arctium lappa L. roots in A beta(1-42)-induced mouse model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwon, Yoon Kyung | - |
dc.contributor.author | Choi, Soo Jung | - |
dc.contributor.author | Kim, Cho Rong | - |
dc.contributor.author | Kim, Jae Kyeom | - |
dc.contributor.author | Kim, Youn-Jung | - |
dc.contributor.author | Choi, Jong Hun | - |
dc.contributor.author | Song, Sang-Wook | - |
dc.contributor.author | Kim, Chang-Ju | - |
dc.contributor.author | Park, Gwi Gun | - |
dc.contributor.author | Park, Cheung-Seog | - |
dc.contributor.author | Shin, Dong-Hoon | - |
dc.date.available | 2020-02-28T00:45:46Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2016-08 | - |
dc.identifier.issn | 2468-0834 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8022 | - |
dc.description.abstract | Many studies have shown that oxidative stress induced by hydrogen peroxide can lead to neuronal cell death. In this study, protective effects of the ethanol extract of A. lappa L. roots against oxidative stress in PC12 cells were measured by 2', 7'-dichlorofluorescein diacetate and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays. Oxidative stress contributes to the memory deficits induced by Beta-amyloid(1-42) in mice. Treatment with the ethanol extract of A. lappa L. roots improved working and reference memory in mice in the Y-maze and passive avoidance tests. To detect the lipid peroxidation levels, malondialdehyde was measured. To purify the bioactive compound, active fractions and components of A. lappa L. roots were isolated by partitioning, open column chromatography, TLC, high-performance liquid chromatography, electron ionization mass spectrometry, and H-1/C-13-nuclear magnetic resonance. We identified the bioactive compound as quinic acid, which is a powerful antioxidant agent. Ultimately, the roots of A. lappa L. may become available as an antioxidant food for Alzheimer's disease patients and those with other oxidative stress-induced disorders. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC APPLIED BIOLOGICAL CHEMISTRY | - |
dc.relation.isPartOf | APPLIED BIOLOGICAL CHEMISTRY | - |
dc.subject | DENSITY-LIPOPROTEIN OXIDATION | - |
dc.subject | ACID-DERIVATIVES | - |
dc.subject | CHLOROGENIC ACID | - |
dc.subject | CAFFEIC ACID | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | NEURONAL CELLS | - |
dc.subject | NITRIC-OXIDE | - |
dc.subject | IN-VITRO | - |
dc.subject | RED WINE | - |
dc.subject | STRESS | - |
dc.title | Antioxidant and cognitive-enhancing activities of Arctium lappa L. roots in A beta(1-42)-induced mouse model | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000379304700007 | - |
dc.identifier.doi | 10.1007/s13765-016-0195-2 | - |
dc.identifier.bibliographicCitation | APPLIED BIOLOGICAL CHEMISTRY, v.59, no.4, pp.553 - 565 | - |
dc.identifier.kciid | ART002158726 | - |
dc.identifier.scopusid | 2-s2.0-84976492308 | - |
dc.citation.endPage | 565 | - |
dc.citation.startPage | 553 | - |
dc.citation.title | APPLIED BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 59 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Park, Gwi Gun | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Amyloid beta | - |
dc.subject.keywordAuthor | Arctium lappa Linne | - |
dc.subject.keywordAuthor | Learning | - |
dc.subject.keywordAuthor | Memory | - |
dc.subject.keywordAuthor | Quinic acid | - |
dc.subject.keywordPlus | DENSITY-LIPOPROTEIN OXIDATION | - |
dc.subject.keywordPlus | ACID-DERIVATIVES | - |
dc.subject.keywordPlus | CHLOROGENIC ACID | - |
dc.subject.keywordPlus | CAFFEIC ACID | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | NEURONAL CELLS | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | RED WINE | - |
dc.subject.keywordPlus | STRESS | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.