The effect of low-dose dexmedetomidine on hemodynamics and anesthetic requirement during bis-spectral index-guided total intravenous anesthesia
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Hee Yeon | - |
dc.contributor.author | Kim, Jong Yeop | - |
dc.contributor.author | Cho, Sang Hyun | - |
dc.contributor.author | Lee, Dongchul | - |
dc.contributor.author | Kwak, Hyun Jeong | - |
dc.date.available | 2020-02-28T01:41:23Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2016-08 | - |
dc.identifier.issn | 1387-1307 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8030 | - |
dc.description.abstract | The purpose of this study was to evaluate the effects of low-dose dexmedetomidine on hemodynamics and anesthetic requirements during propofol and remifentanil anesthesia for laparoscopic cholecystectomy. Thirty adult patients were randomly allocated to receive dexmedetomidine infusion of 0.3 mu g/kg/h (dexmedetomidine group, n = 15) or comparable volumes of saline infusion (control group, n = 15). Target controlled infusion of propofol and remifentanil was used for anesthetic induction and maintenance, and adjusted in order to maintain a bispectral index of 40-55 and hemodynamic stability. We measured hemodynamics and recorded total and mean infused dosages of propofol and remifentanil. For anesthesia induction and maintenance, mean infused doses of propofol (121 +/- 27 vs. 144 +/- 29 mu g/kg/min, P = 0.04) and remifentanil (118 +/- 27 vs. 150 +/- 36 ng/kg/min, P = 0.01) were lower in the dexmedetomidine group than in the control group, respectively. The dexmedetomidine group required 16 % less propofol and 23 % less remifentanil. During anesthetic induction and maintenance, the dexmedetomidine group required fewer total doses of propofol (9.6 +/- 2.3 vs. 12.4 +/- 3.3 mg/kg, P = 0.01) and remifentanil (9.6 +/- 3.4 vs. 12.7 +/- 2.6 mu g/kg, P = 0.01). The change in mean arterial pressure over time differed between the groups (P < 0.05). Significantly lower mean arterial pressure was observed in the dexmedetomidine group than in the control group at immediately and 5 min after pneumoperitoneum. The time to extubation after completion of drug administration did not differ between the groups (P = 0.25). This study demonstrated that a low-dose dexmedetomidine infusion of 0.3 mu g/kg/h reduced propofol and remifentanil requirements as well as hemodynamic change by pneumoperitoneum without delayed recovery during propofol-remifentanil anesthesia for laparoscopic cholecystectomy. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MONITORING AND COMPUTING | - |
dc.subject | LAPAROSCOPIC CHOLECYSTECTOMY | - |
dc.subject | PROPOFOL | - |
dc.subject | INFUSION | - |
dc.subject | SURGERY | - |
dc.subject | REMIFENTANIL | - |
dc.subject | PHARMACODYNAMICS | - |
dc.subject | VOLUNTEERS | - |
dc.subject | HUMANS | - |
dc.subject | ADULT | - |
dc.subject | AGE | - |
dc.title | The effect of low-dose dexmedetomidine on hemodynamics and anesthetic requirement during bis-spectral index-guided total intravenous anesthesia | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000380266200007 | - |
dc.identifier.doi | 10.1007/s10877-015-9735-2 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MONITORING AND COMPUTING, v.30, no.4, pp.429 - 435 | - |
dc.identifier.scopusid | 2-s2.0-84979530163 | - |
dc.citation.endPage | 435 | - |
dc.citation.startPage | 429 | - |
dc.citation.title | JOURNAL OF CLINICAL MONITORING AND COMPUTING | - |
dc.citation.volume | 30 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Park, Hee Yeon | - |
dc.contributor.affiliatedAuthor | Lee, Dongchul | - |
dc.contributor.affiliatedAuthor | Kwak, Hyun Jeong | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Anesthetic requirement | - |
dc.subject.keywordAuthor | Dexmedetomidine | - |
dc.subject.keywordAuthor | Hemodynamics | - |
dc.subject.keywordAuthor | Propofol | - |
dc.subject.keywordAuthor | Remifentanil | - |
dc.subject.keywordPlus | LAPAROSCOPIC CHOLECYSTECTOMY | - |
dc.subject.keywordPlus | PROPOFOL | - |
dc.subject.keywordPlus | INFUSION | - |
dc.subject.keywordPlus | SURGERY | - |
dc.subject.keywordPlus | REMIFENTANIL | - |
dc.subject.keywordPlus | PHARMACODYNAMICS | - |
dc.subject.keywordPlus | VOLUNTEERS | - |
dc.subject.keywordPlus | HUMANS | - |
dc.subject.keywordPlus | ADULT | - |
dc.subject.keywordPlus | AGE | - |
dc.relation.journalResearchArea | Anesthesiology | - |
dc.relation.journalWebOfScienceCategory | Anesthesiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.