Cerebellar Development in Preterm Infants at Term-Equivalent Age Is Impaired after Low-Grade Intraventricular Hemorrhage
DC Field | Value | Language |
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dc.contributor.author | Jeong, Hye Jin | - |
dc.contributor.author | Shim, So-Yeon | - |
dc.contributor.author | Cho, Hye Jung | - |
dc.contributor.author | Cho, Su Jin | - |
dc.contributor.author | Son, Dong Woo | - |
dc.contributor.author | Park, Eun Ae | - |
dc.date.available | 2020-02-28T01:41:26Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2016-08 | - |
dc.identifier.issn | 0022-3476 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8035 | - |
dc.description.abstract | Objectives To investigate cerebellar development in preterm infants at term-equivalent age compared with healthy full-term infants and to examine the effect of a low-grade intraventricular hemorrhage (IVH) on cerebellar development. Study design This study used 3T magnetic resonance and diffusion tensor imaging (DTI) at 36-41 weeks' post-menstrual age (PMA) in 72 preterm infants without severe brain injury and 16 full-term infants. Cerebellar volumes and DTI parameters of the cerebellar peduncles including fractional anisotropy (FA), apparent diffusion coefficient (ADC), axial diffusivity, and radial diffusivities were measured. Clinical variables that may affect brain development were collected. Results Compared with full-term infants, preterm infants showed smaller cerebellar volumes and a lower FA, greater ADC, and increased radial diffusivities in the cerebellar peduncles (all P < .05). This cerebellar impairment was associated significantly with PMA and IVH grade 2 but was independent of gestational age at birth. When we adjusted for clinical variables, an IVH grade 2 was related with 1.73 cm 3 reduction in cerebellar volumes and altered DTI parameters in the cerebellar peduncles, including decreased FA and increased radial diffusivities in the superior cerebellar peduncle and increases in ADC, axial diffusivity, and radial diffusivities of the middle cerebellar peduncle (all P < .05). Cerebellar hemispheric volumes were associated with both ipsilateral and contralateral IVH grade 2. Conclusion Preterminfants without severe brain abnormalities showed impaired cerebellar development at term-equivalent age after we controlled for PMA at the time of the scan, and this is associated with IVH grade 2. These findings suggest that even a low-grade IVH has potential harmful effects on cerebellar development. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MOSBY-ELSEVIER | - |
dc.relation.isPartOf | JOURNAL OF PEDIATRICS | - |
dc.subject | WHITE-MATTER | - |
dc.subject | BRAIN-INJURY | - |
dc.subject | SCHOOL-AGE | - |
dc.subject | DIFFUSION | - |
dc.subject | BIRTH | - |
dc.subject | GROWTH | - |
dc.subject | PREMATURITY | - |
dc.subject | MATURATION | - |
dc.subject | CHILDREN | - |
dc.subject | VOLUMES | - |
dc.title | Cerebellar Development in Preterm Infants at Term-Equivalent Age Is Impaired after Low-Grade Intraventricular Hemorrhage | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000380835500022 | - |
dc.identifier.doi | 10.1016/j.jpeds.2016.05.010 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PEDIATRICS, v.175, pp.86 - + | - |
dc.identifier.scopusid | 2-s2.0-85008698696 | - |
dc.citation.endPage | + | - |
dc.citation.startPage | 86 | - |
dc.citation.title | JOURNAL OF PEDIATRICS | - |
dc.citation.volume | 175 | - |
dc.contributor.affiliatedAuthor | Jeong, Hye Jin | - |
dc.contributor.affiliatedAuthor | Cho, Hye Jung | - |
dc.contributor.affiliatedAuthor | Son, Dong Woo | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | cerebellar peduncle | - |
dc.subject.keywordAuthor | cerebellar volume | - |
dc.subject.keywordAuthor | diffusion tensor imaging | - |
dc.subject.keywordPlus | WHITE-MATTER | - |
dc.subject.keywordPlus | BRAIN-INJURY | - |
dc.subject.keywordPlus | SCHOOL-AGE | - |
dc.subject.keywordPlus | DIFFUSION | - |
dc.subject.keywordPlus | BIRTH | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | PREMATURITY | - |
dc.subject.keywordPlus | MATURATION | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | VOLUMES | - |
dc.relation.journalResearchArea | Pediatrics | - |
dc.relation.journalWebOfScienceCategory | Pediatrics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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