Minimally invasive and continuous glucose monitoring sensor based on non-enzymatic porous platinum black-coated gold microneedles
DC Field | Value | Language |
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dc.contributor.author | Chinnadayyala, S.R. | - |
dc.contributor.author | Park, Jinsoo | - |
dc.contributor.author | Satti, A.T. | - |
dc.contributor.author | Kim, Daeyoung | - |
dc.contributor.author | Cho, Sungbo | - |
dc.date.available | 2021-03-11T03:40:17Z | - |
dc.date.created | 2021-01-20 | - |
dc.date.issued | 2021-02 | - |
dc.identifier.issn | 0013-4686 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/80382 | - |
dc.description.abstract | Individuals with diabetes can considerably benefit from continuous glucose monitoring (CGM). Addressing this challenge, a proof-of-concept for a pain-free CGM was presented based on a highly porous platinum black (Pt-black)-modified non-enzymatic microneedle electrode arrays (MNEAs). Porous Pt-black was electrodeposited on microneedle substrates using potentiometry by employing a charge density of -2.5 mA cm˗2. The surface of the porous Pt-black-modified microneedles (MNs) was optimally packed using Nafion (Nf) biocompatible ionomer. The dimensions of the fabricated microneedles were 650 µm × 110 µm × 150 µm in height, width, and thickness, respectively. The surface morphology of the modified MNs was studied using scanning electron microscopy (SEM) and energy dispersive X-ray analysis (EDX). The microneedle sensor showed a wide glucose dynamic range (1 − 20 mM) in phosphate buffer saline (PBS) and artificial interstitial fluid (ISF) in-vitro with good sensitivities (PBS: 5.786 µA mM−1 cm−2, ISF: 4.380 µA mM−1 cm−2), detection limits (PBS: 10 µM, ISF: 22.5 µM), stability (2% lost at the end of 7 h), selectivity, reproducibility (2.32% RSD), and a response time of 2 s with good glucose recoveries in ISF (98%-102.5%). The device exhibited good stability (7 days) as a sensor in-vivo and lost its functional activity after 7 days due to electrode biofouling. © 2020 | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | Electrochimica Acta | - |
dc.title | Minimally invasive and continuous glucose monitoring sensor based on non-enzymatic porous platinum black-coated gold microneedles | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000612049700010 | - |
dc.identifier.doi | 10.1016/j.electacta.2020.137691 | - |
dc.identifier.bibliographicCitation | Electrochimica Acta, v.369 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85099043414 | - |
dc.citation.title | Electrochimica Acta | - |
dc.citation.volume | 369 | - |
dc.contributor.affiliatedAuthor | Chinnadayyala, S.R. | - |
dc.contributor.affiliatedAuthor | Park, Jinsoo | - |
dc.contributor.affiliatedAuthor | Satti, A.T. | - |
dc.contributor.affiliatedAuthor | Kim, Daeyoung | - |
dc.contributor.affiliatedAuthor | Cho, Sungbo | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Chronoamperometry | - |
dc.subject.keywordAuthor | Electrochemical impedance spectroscopy | - |
dc.subject.keywordAuthor | Electrodeposition | - |
dc.subject.keywordAuthor | Interstitial fluid | - |
dc.subject.keywordAuthor | Microelectromechanical systems | - |
dc.subject.keywordAuthor | Microneedle electrode array | - |
dc.subject.keywordPlus | Biocompatibility | - |
dc.subject.keywordPlus | Electrodes | - |
dc.subject.keywordPlus | Energy dispersive X ray analysis | - |
dc.subject.keywordPlus | Glucose | - |
dc.subject.keywordPlus | Gold coatings | - |
dc.subject.keywordPlus | Morphology | - |
dc.subject.keywordPlus | Platinum | - |
dc.subject.keywordPlus | Scanning electron microscopy | - |
dc.subject.keywordPlus | Surface morphology | - |
dc.subject.keywordPlus | X ray diffraction analysis | - |
dc.subject.keywordPlus | Continuous glucose monitoring sensors | - |
dc.subject.keywordPlus | Continuous glucosemonitoring (CGM) | - |
dc.subject.keywordPlus | Energy dispersive x-ray analysis (EDX) | - |
dc.subject.keywordPlus | Functional activities | - |
dc.subject.keywordPlus | Interstitial fluids (ISF) | - |
dc.subject.keywordPlus | Minimally invasive | - |
dc.subject.keywordPlus | Phosphate buffer salines | - |
dc.subject.keywordPlus | Reproducibilities | - |
dc.subject.keywordPlus | Needles | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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