Experimental study on gastroprotective efficacy and mechanisms of luteolin-7-O-glucoside isolated from Ophiorrhiza mungos Linn. in different experimental models
DC Field | Value | Language |
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dc.contributor.author | Antonisamy, Paulrayer | - |
dc.contributor.author | Subash-Babu, Pandurangan | - |
dc.contributor.author | Albert-Baskar, Arul | - |
dc.contributor.author | Alshatwi, Ali A. | - |
dc.contributor.author | Aravinthan, Adithan | - |
dc.contributor.author | Ignacimuthu, Savarimuthu | - |
dc.contributor.author | Choi, Ki Choon | - |
dc.contributor.author | Lee, Sung Cheol | - |
dc.contributor.author | Kim, Jong-Hoon | - |
dc.date.available | 2020-02-28T01:41:32Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2016-08 | - |
dc.identifier.issn | 1756-4646 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8040 | - |
dc.description.abstract | The gastroprotective effect of luteolin-7-O-glucoside (LUT7G) on different ulcer models using rats including the indomethacin model, the ethanol-induced gastric ulcer model and the Shay ulcer model was examined. The ethanol-induced ulcer group showed significant increases in MPO, NO, iNOS, MMP-2, MMP-9, caspase-3, apoptosis, IL-6, TNF-alpha, IKK, NF-kappa B, p65, and ICAM-1 and declines in PGE2, arginase, SOD, GSH, mucin, IL-10, eNOS, COX-1, HSP-70, and I kappa B alpha levels. However, LUT7G (25 mg/kg) pretreatment significantly reverted the pathophysiological levels of these biomarkers to near normal levels. The gastroprotective activity of LUT7G was abolished by pretreatment with SC560, rofecoxib, and L-NAME, demonstrating the participation of COX and NOS in LUT7G-facilitated gastroprotection against ethanol induced ulcers. Convincingly, LUT7G (25 mg/kg) provided protective effects in the rat gastric mucosa against ethanol-induced gastric injury at least in part to antisecretory, anti-inflammatory, antioxidative, and antiapoptotic activity, and augmentation of PGE2, mucin and HSP-70 synthesis. (C) 2016 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | JOURNAL OF FUNCTIONAL FOODS | - |
dc.subject | ACUTE HEMORRHAGIC GASTRITIS | - |
dc.subject | HELICOBACTER-PYLORI | - |
dc.subject | LIPID-PEROXIDATION | - |
dc.subject | EPITHELIAL-CELLS | - |
dc.subject | NITRIC-OXIDE | - |
dc.subject | KAPPA-B | - |
dc.subject | ULCER | - |
dc.subject | RATS | - |
dc.subject | APOPTOSIS | - |
dc.subject | ETHANOL | - |
dc.title | Experimental study on gastroprotective efficacy and mechanisms of luteolin-7-O-glucoside isolated from Ophiorrhiza mungos Linn. in different experimental models | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000381234200026 | - |
dc.identifier.doi | 10.1016/j.jff.2016.06.003 | - |
dc.identifier.bibliographicCitation | JOURNAL OF FUNCTIONAL FOODS, v.25, pp.302 - 313 | - |
dc.identifier.scopusid | 2-s2.0-84975801370 | - |
dc.citation.endPage | 313 | - |
dc.citation.startPage | 302 | - |
dc.citation.title | JOURNAL OF FUNCTIONAL FOODS | - |
dc.citation.volume | 25 | - |
dc.contributor.affiliatedAuthor | Albert-Baskar, Arul | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Gastroprotective activity | - |
dc.subject.keywordAuthor | Ethanol-induced gastric injury | - |
dc.subject.keywordAuthor | Oxidative stress | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | LUT7G | - |
dc.subject.keywordAuthor | Ophiorrhiza mungos | - |
dc.subject.keywordPlus | ACUTE HEMORRHAGIC GASTRITIS | - |
dc.subject.keywordPlus | HELICOBACTER-PYLORI | - |
dc.subject.keywordPlus | LIPID-PEROXIDATION | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | KAPPA-B | - |
dc.subject.keywordPlus | ULCER | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | ETHANOL | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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