Ca2+ Signaling as the Untact Mode during Signaling in Metastatic Breast Cancer
DC Field | Value | Language |
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dc.contributor.author | Lee, Dongun | - |
dc.contributor.author | Hong, Jeong Hee | - |
dc.date.available | 2021-04-08T00:40:17Z | - |
dc.date.created | 2021-03-29 | - |
dc.date.issued | 2021-03 | - |
dc.identifier.issn | 2072-6694 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/80675 | - |
dc.description.abstract | Metastatic features of breast cancer in the brain are considered a common pathology in female patients with late-stage breast cancer. Ca2+ signaling and the overexpression pattern of Ca2+ channels have been regarded as oncogenic markers of breast cancer. In other words, breast tumor development can be mediated by inhibiting Ca2+ channels. Although the therapeutic potential of inhibiting Ca2+ channels against breast cancer has been demonstrated, the relationship between breast cancer metastasis and Ca2+ channels is not yet understood. Thus, we focused on the metastatic features of breast cancer and summarized the basic mechanisms of Ca2+-related proteins and channels during the stages of metastatic breast cancer by evaluating Ca2+ signaling. In particular, we highlighted the metastasis of breast tumors to the brain. Thus, modulating Ca2+ channels with Ca2+ channel inhibitors and combined applications will advance treatment strategies for breast cancer metastasis to the brain. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | Cancers | - |
dc.title | Ca2+ Signaling as the Untact Mode during Signaling in Metastatic Breast Cancer | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000634347100001 | - |
dc.identifier.doi | 10.3390/cancers13061473 | - |
dc.identifier.bibliographicCitation | Cancers, v.13, no.6 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85102848442 | - |
dc.citation.title | Cancers | - |
dc.citation.volume | 13 | - |
dc.citation.number | 6 | - |
dc.contributor.affiliatedAuthor | Lee, Dongun | - |
dc.contributor.affiliatedAuthor | Hong, Jeong Hee | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | Brain metastasis | - |
dc.subject.keywordAuthor | Breast cancer | - |
dc.subject.keywordAuthor | Ca2+ channels | - |
dc.subject.keywordAuthor | Ca2+ signaling | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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