Drug-induced Parkinsonism: A strong predictor of idiopathic Parkinson's disease
DC Field | Value | Language |
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dc.contributor.author | Jeong, Sohyun | - |
dc.contributor.author | Cho, Hyemin | - |
dc.contributor.author | Kim, Yun Joong | - |
dc.contributor.author | Ma, Hyeo-Il | - |
dc.contributor.author | Jang, Sunmee | - |
dc.date.available | 2021-04-12T00:40:29Z | - |
dc.date.created | 2021-03-18 | - |
dc.date.issued | 2021-03-01 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/80694 | - |
dc.description.abstract | BACKGROUND: Although Idiopathic Parkinson's disease (IPD) develops in considerable patients with drug-induced Parkinsonism (DIP), the association hasn't been well defined. We aimed to evaluate the underlying association and risk factors of DIP and IPD. METHODS: A retrospective cohort study using National Health Insurance Claims data in 2011-2016 was conducted. New-onset DIP patients in 2012 were selected and matched with active controls having diabetes mellitus at a 1:4 ratio by age, sex, and Charlson's Comorbidity Index score. Comorbidity, causative drugs, and prescription days were evaluated as covariates. RESULTS: A total of 441 DIP were selected. During the 4-year follow up, 14 IPD events in the DM group but 62 events in the DIP group were observed (adjusted hazard ratio, HR: 18.88, 95% CI, 9.09-39.22, adjusting for comorbidities and causative drugs). IPD diagnosis in DIP was observed high in males compared to females (15.58/13.24%). The event was the most within the 1st year follow-up, mean days 453 (SD 413.36). Subgroup analysis in DIP showed calcium channel blocker (verapamil, diltiazem, and flunarizine) was significantly associated with increased IPD risk (HR: 2.24, 95% CI, 1.27-3.93). CONCLUSION: Increased IPD in DIP patients might not be from the causal toxicity of antidopaminergic effects but from a trigger by the causative drugs on the DIP patients who already had subclinical IPD pathology. DIP can serve as a strong proxy for IPD incidence. Subjects who develop DIP should be monitored carefully for potential IPD incidence. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLoS ONE | - |
dc.title | Drug-induced Parkinsonism: A strong predictor of idiopathic Parkinson's disease | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000625328100037 | - |
dc.identifier.doi | 10.1371/journal.pone.0247354 | - |
dc.identifier.bibliographicCitation | PLoS ONE, v.16, no.3 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85102331662 | - |
dc.citation.title | PLoS ONE | - |
dc.citation.volume | 16 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Cho, Hyemin | - |
dc.contributor.affiliatedAuthor | Jang, Sunmee | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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