ASK1 is Involved in EBV LMP1-induced NF-κB Activation
DC Field | Value | Language |
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dc.contributor.author | 송윤재 | - |
dc.date.available | 2021-04-20T04:05:43Z | - |
dc.date.created | 2021-04-20 | - |
dc.date.issued | 2012-03 | - |
dc.identifier.issn | 1598-2467 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/80794 | - |
dc.description.abstract | Epstein-Barr virus (EBV) latent infection transforms B lymphocytes into proliferating lymphoblastoid cell lines (LCLs). EBV latent infection membrane protein 1 (LMP1) is required for EBV-mediated B lymphocyte transformation, and LMP1-induced NF-κB activation is essential for LCL survival. Previously, it was reported that the level of reactive oxygen species (ROS) and the expression of apoptosis signal-regulating kinase 1 (ASK1) are elevated in EBV-positive Burkitt's lymphoma (BL) cells, the potential role of ASK1 in LMP1-induced NF-κB activation was thus investigated in this study. In EBV-positive BL cells, ASK1 was highly expressed and activated. In addition, TRAF6-ASK1 interaction was significantly increased in EBV-positive BL cells. Interestingly, the expression of LMP1 alone facilitated ASK1activation. The expression of a dominant negative ASK1 mutant (ASK1KM) strongly blocked LMP1-induced NF-κB activation. Furthermore, LMP1-induced NF-κB activation was significantly reduced in ASK1 knock out (ASK1-/-)mouse embryonic fibroblasts (MEFs). Taken together, these results demonstrate that ASK1 is activated by LMP1 and is critical for LMP1-induced NF-κB activation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한미생물학회 | - |
dc.relation.isPartOf | Journal of Bacteriology and Virology | - |
dc.title | ASK1 is Involved in EBV LMP1-induced NF-κB Activation | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.doi | 10.4167/jbv.2012.42.1.63 | - |
dc.identifier.bibliographicCitation | Journal of Bacteriology and Virology, v.42, no.1, pp.63 - 68 | - |
dc.identifier.kciid | ART001647441 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85033331363 | - |
dc.citation.endPage | 68 | - |
dc.citation.startPage | 63 | - |
dc.citation.title | Journal of Bacteriology and Virology | - |
dc.citation.volume | 42 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | 송윤재 | - |
dc.subject.keywordAuthor | Epstein-Barr virus | - |
dc.subject.keywordAuthor | Latent membrane protein 1 | - |
dc.subject.keywordAuthor | ASK1 | - |
dc.subject.keywordAuthor | NF-κB | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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