Surface Functionalization of Doxorubicin loaded MCM-41 Mesoporous Silica Nanoparticles by 3-Aminopropyltriethoxysilane for Selective Anticancer 9 Effect on A549 and A549/DOX Cells
DC Field | Value | Language |
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dc.contributor.author | Dau, T.A.N. | - |
dc.contributor.author | Le, V.M.H. | - |
dc.contributor.author | Pham, T.K.H. | - |
dc.contributor.author | Le, V.H. | - |
dc.contributor.author | Cho, S.K. | - |
dc.contributor.author | Nguyen, T.N.U. | - |
dc.contributor.author | Ta, T.K.H. | - |
dc.contributor.author | Van, Tran T.T. | - |
dc.date.available | 2021-04-26T01:05:27Z | - |
dc.date.created | 2021-03-22 | - |
dc.date.issued | 2021-05 | - |
dc.identifier.issn | 0361-5235 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/80839 | - |
dc.description.abstract | Abstract: In this study, MCM-41 mesoporous silica nanoparticles were successfully synthesized by the condensation of a tetraorthosilicate precursor on a template self-assembled by cetyltrimethylammonium bromide in alkaline. The small-angle x-ray diffraction patterns of MCM-41 indicate that silica nanoparticles possess hexagonal structures with a high degree of structural ordering. Transmission electron microscopy images show that the size of the MCM-41 particles is around 100-120 nm, and the pore sizes range from 2 nm to 4 nm. In addition, the specific surface area of MCM-41 obtained by Brunauer–Emmett–Teller analysis is as high as 987 m2.g−1 and the pore size extracted from nitrogen physical adsorption isotherms is in accordance with the TEM result. Thermogravimetric analysis, Fourier-transform infrared spectroscopy, Zeta potential measurements and photoluminescence measurements show that 3-aminopropyltriethoxysilane (APTES) and doxorubicin were grafted and loaded successfully onto MCM-41 nanoparticles. An assay on fibroblasts, A549 and doxorubicin-resistant A549/DOX cells indicates that the prepared MCM41 grafting APTES nanoparticles are safe to normal cells and toxic to cancer cells in vitro. Graphic abstract: [Figure not available: see fulltext.] © 2021, The Minerals, Metals & Materials Society. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.relation.isPartOf | Journal of Electronic Materials | - |
dc.title | Surface Functionalization of Doxorubicin loaded MCM-41 Mesoporous Silica Nanoparticles by 3-Aminopropyltriethoxysilane for Selective Anticancer 9 Effect on A549 and A549/DOX Cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000627192600001 | - |
dc.identifier.doi | 10.1007/s11664-021-08813-y | - |
dc.identifier.bibliographicCitation | Journal of Electronic Materials, v.50, no.5, pp.2932 - 2939 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85102452103 | - |
dc.citation.endPage | 2939 | - |
dc.citation.startPage | 2932 | - |
dc.citation.title | Journal of Electronic Materials | - |
dc.citation.volume | 50 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Pham, T.K.H. | - |
dc.type.docType | Article in Press | - |
dc.subject.keywordAuthor | A549 | - |
dc.subject.keywordAuthor | A549/DOX | - |
dc.subject.keywordAuthor | doxorubicin | - |
dc.subject.keywordAuthor | MCM-41 | - |
dc.subject.keywordAuthor | Mesoporous silica nanoparticles | - |
dc.subject.keywordPlus | Cell culture | - |
dc.subject.keywordPlus | Cells | - |
dc.subject.keywordPlus | Fourier transform infrared spectroscopy | - |
dc.subject.keywordPlus | Gas adsorption | - |
dc.subject.keywordPlus | Grafting (chemical) | - |
dc.subject.keywordPlus | High resolution transmission electron microscopy | - |
dc.subject.keywordPlus | Nanoparticles | - |
dc.subject.keywordPlus | Particle size analysis | - |
dc.subject.keywordPlus | Pore size | - |
dc.subject.keywordPlus | Silica | - |
dc.subject.keywordPlus | Synthesis (chemical) | - |
dc.subject.keywordPlus | Thermogravimetric analysis | - |
dc.subject.keywordPlus | 3-aminopropyltriethoxysilane | - |
dc.subject.keywordPlus | Cetyl trimethyl ammonium bromides | - |
dc.subject.keywordPlus | Degree of structural order | - |
dc.subject.keywordPlus | Photoluminescence measurements | - |
dc.subject.keywordPlus | Small-angle X-ray diffraction patterns | - |
dc.subject.keywordPlus | Surface Functionalization | - |
dc.subject.keywordPlus | Transmission electron microscopy images | - |
dc.subject.keywordPlus | Zeta potential measurements | - |
dc.subject.keywordPlus | Silica nanoparticles | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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