Akt and calcium-permeable AMPA receptor are involved in the effect of pinoresinol on amyloid β-induced synaptic plasticity and memory deficits
DC Field | Value | Language |
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dc.contributor.author | Yu, Jimin | - |
dc.contributor.author | Cho, Eunbi | - |
dc.contributor.author | Kwon, Huiyoung | - |
dc.contributor.author | Jeon, Jieun | - |
dc.contributor.author | Sin, Jae Seong | - |
dc.contributor.author | Park, Jun Kwon | - |
dc.contributor.author | Kim, Ji-Su | - |
dc.contributor.author | Choi, Ji Woong | - |
dc.contributor.author | Park, Se Jin | - |
dc.contributor.author | Jun, Mira | - |
dc.contributor.author | Lee, Young Choon | - |
dc.contributor.author | Ryu, Jong Hoon | - |
dc.contributor.author | Lee, Jeongwon | - |
dc.contributor.author | Moon, Minho | - |
dc.contributor.author | Lee, Seungheon | - |
dc.contributor.author | Cho, Jong Hyun | - |
dc.contributor.author | Kim, Dong Hyun | - |
dc.date.accessioned | 2021-05-12T00:40:14Z | - |
dc.date.available | 2021-05-12T00:40:14Z | - |
dc.date.created | 2021-01-20 | - |
dc.date.issued | 2021-02 | - |
dc.identifier.issn | 0006-2952 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/80985 | - |
dc.description.abstract | Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders characterized by memory deficits. Although no drug has given promising results, synaptic dysfunction-modulating agents might be considered potential candidates for alleviating this disorder. Pinoresinol, a lignan found in Forsythia suspensa, is a memory-enhancing agent with excitatory synaptic activation. In the present study, we tested whether pinoresinol reduces learning and memory and excitatory synaptic deficits in an amyloid β (Aβ)-induced AD-like mouse model. Pinoresinol enhanced hippocampal long-term potentiation (LTP) through calcium-permeable AMPA receptor, which was mediated by Akt activation. Moreover, pinoresinol ameliorated LTP deficits in amyloid β (Aβ)-treated hippocampal slices via Akt signaling. Oral administration of pinoresinol ameliorated Aβ-induced memory deficits without sensory dysfunction. Moreover, AD-like pathology, including neuroinflammation and synaptic deficit, were ameliorated by pinoresinol administration. Collectively, pinoresinol may be a good candidate for AD therapy by modulating synaptic functions. © 2020 | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | Biochemical Pharmacology | - |
dc.title | Akt and calcium-permeable AMPA receptor are involved in the effect of pinoresinol on amyloid β-induced synaptic plasticity and memory deficits | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000640525100008 | - |
dc.identifier.doi | 10.1016/j.bcp.2020.114366 | - |
dc.identifier.bibliographicCitation | Biochemical Pharmacology, v.184 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85097897880 | - |
dc.citation.title | Biochemical Pharmacology | - |
dc.citation.volume | 184 | - |
dc.contributor.affiliatedAuthor | Choi, Ji Woong | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Akt | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | Calcium-permeable AMPA receptor | - |
dc.subject.keywordAuthor | Long-term potentiation | - |
dc.subject.keywordAuthor | Pinoresinol | - |
dc.subject.keywordPlus | AMPA receptor | - |
dc.subject.keywordPlus | amyloid beta protein | - |
dc.subject.keywordPlus | calcium | - |
dc.subject.keywordPlus | donepezil | - |
dc.subject.keywordPlus | glial fibrillary acidic protein | - |
dc.subject.keywordPlus | n methyl dextro aspartic acid receptor | - |
dc.subject.keywordPlus | pinoresinol | - |
dc.subject.keywordPlus | protein kinase B | - |
dc.subject.keywordPlus | Akt signaling | - |
dc.subject.keywordPlus | Alzheimer disease | - |
dc.subject.keywordPlus | amnesia | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal model | - |
dc.subject.keywordPlus | animal tissue | - |
dc.subject.keywordPlus | antiinflammatory activity | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | astrocyte | - |
dc.subject.keywordPlus | chemoluminescence | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | enzyme activation | - |
dc.subject.keywordPlus | excitatory postsynaptic potential | - |
dc.subject.keywordPlus | hippocampal slice | - |
dc.subject.keywordPlus | hippocampal tissue | - |
dc.subject.keywordPlus | hippocampus | - |
dc.subject.keywordPlus | immunohistochemistry | - |
dc.subject.keywordPlus | latent period | - |
dc.subject.keywordPlus | learning | - |
dc.subject.keywordPlus | long term potentiation | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | mouse | - |
dc.subject.keywordPlus | nerve cell plasticity | - |
dc.subject.keywordPlus | nervous system inflammation | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | passive avoidance test | - |
dc.subject.keywordPlus | phosphorylation | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | protein function | - |
dc.subject.keywordPlus | Schaffer collateral pathway | - |
dc.subject.keywordPlus | Western blotting | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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