Comparison of short-term clinical outcomes between ticagrelor versus clopidogrel in patients with acute myocardial infarction undergoing successful revascularization; from Korea Acute Myocardial Infarction Registry-National Institute of Health
DC Field | Value | Language |
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dc.contributor.author | Park, Keun-Ho | - |
dc.contributor.author | Jeong, Myung Ho | - |
dc.contributor.author | Ahn, Youngkeun | - |
dc.contributor.author | Ahn, Tae Hoon | - |
dc.contributor.author | Seung, Ki Bae | - |
dc.contributor.author | Oh, Dong Joo | - |
dc.contributor.author | Choi, Dong-Joo | - |
dc.contributor.author | Kim, Hyo-Soo | - |
dc.contributor.author | Gwon, Hyeon Cheol | - |
dc.contributor.author | Seong, InWhan | - |
dc.contributor.author | Hwang, Kyung Kuk | - |
dc.contributor.author | Chae, Shung Chull | - |
dc.contributor.author | Kim, Kwon-Bae | - |
dc.contributor.author | Kim, Young Jo | - |
dc.contributor.author | Cha, Kwang Soo | - |
dc.contributor.author | Oh, Seok Kyu | - |
dc.contributor.author | Chae, Jei Keon | - |
dc.date.available | 2020-02-28T01:42:48Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2016-07-15 | - |
dc.identifier.issn | 0167-5273 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8100 | - |
dc.description.abstract | Background: Although ticagrelor has been well-known to improve clinical outcomes in patients with acute myocardial infarction (AMI) without increased bleeding risk, its clinical impacts have not been well established in East Asian patients. Methods: Between November 2011 and June 2015, a total of 8010 patients (1377 patients were prescribed ticagrelor and 6633 patients clopidogrel) undergoing successful revascularization were analyzed from Korea Acute Myocardial Infarction Registry-National Institute of Health. The patients who discontinued or occurred in-hospital switching between two antiplatelet agents were excluded. Results: After propensity score matching (1377 pairs), no difference in the composite of cardiac death, MI, stroke, or target vessel revascularization at 6 months was observed between two groups (4.2% vs. 4.9%, p = 0.499). However, the incidences of in-hospital Thrombolysis In Myocardial Infarction (TIMI) major and minor bleeding were higher in ticagrelor than clopidogrel (2.6% vs. 1.2%, p = 0.008; 3.8% vs. 2.5%, p = 0.051). The in-hospital mortality was higher in patients with than those without TIMI major bleeding (11.3% vs. 0.9%, p < 0.001). In a subgroup analysis, a higher risk for in-hospital TIMI major bleeding with ticagrelor was observed in patients = 75 years or with body weight < 60 kg (odd ratio [OR] = 3.209; 95% confidence interval [CI] = 1.356-7.592) and in those received trans-femoral intervention (OR = 1.996; 95% CI = 1.061-3.754). Conclusions: Our study shows that ticagrelor did not reduce ischemic events yet, however, was associated with increased risk of bleeding complications compared with clopidogrel. Further large-scale, long-term, randomized trials should be required to assess the outcomes of ticagrelor for East Asian patients with AMI. (C) 2016 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CARDIOLOGY | - |
dc.subject | ACUTE CORONARY SYNDROME | - |
dc.subject | TREATMENT PLATELET REACTIVITY | - |
dc.subject | DRUG-ELUTING STENTS | - |
dc.subject | ANTIPLATELET-THERAPY | - |
dc.subject | ASIAN PATIENTS | - |
dc.subject | ST-ELEVATION | - |
dc.subject | THROMBOSIS | - |
dc.subject | RISK | - |
dc.subject | INTERVENTION | - |
dc.subject | IMPLANTATION | - |
dc.title | Comparison of short-term clinical outcomes between ticagrelor versus clopidogrel in patients with acute myocardial infarction undergoing successful revascularization; from Korea Acute Myocardial Infarction Registry-National Institute of Health | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000376297100047 | - |
dc.identifier.doi | 10.1016/j.ijcard.2016.04.044 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CARDIOLOGY, v.215, pp.193 - 200 | - |
dc.identifier.scopusid | 2-s2.0-84964350709 | - |
dc.citation.endPage | 200 | - |
dc.citation.startPage | 193 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF CARDIOLOGY | - |
dc.citation.volume | 215 | - |
dc.contributor.affiliatedAuthor | Ahn, Tae Hoon | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Myocardial infarction | - |
dc.subject.keywordAuthor | Ticagrelor | - |
dc.subject.keywordAuthor | Hemorrhage | - |
dc.subject.keywordAuthor | Far East | - |
dc.subject.keywordPlus | ACUTE CORONARY SYNDROME | - |
dc.subject.keywordPlus | TREATMENT PLATELET REACTIVITY | - |
dc.subject.keywordPlus | DRUG-ELUTING STENTS | - |
dc.subject.keywordPlus | ANTIPLATELET-THERAPY | - |
dc.subject.keywordPlus | ASIAN PATIENTS | - |
dc.subject.keywordPlus | ST-ELEVATION | - |
dc.subject.keywordPlus | THROMBOSIS | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | INTERVENTION | - |
dc.subject.keywordPlus | IMPLANTATION | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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