Valsartan Dosage on Ventriculo-Vascular Coupling Index Dose-Dependency in Heart Failure Patients
DC Field | Value | Language |
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dc.contributor.author | 안경진 | - |
dc.contributor.author | 유종욱 | - |
dc.contributor.author | 장영우 | - |
dc.contributor.author | 김대혁 | - |
dc.contributor.author | 권준 | - |
dc.contributor.author | 정욱진 | - |
dc.date.accessioned | 2021-05-24T02:40:16Z | - |
dc.date.available | 2021-05-24T02:40:16Z | - |
dc.date.created | 2021-04-27 | - |
dc.date.issued | 2021-05 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81067 | - |
dc.description.abstract | Purpose: Heart failure (HF) poses significant morbidity and mortality. Recently, the ventriculo-vascular coupling index (VVI) wasintroduced as an independent prognostic factor reflective of the overall cardiovascular performance index in HF. We aimed to determinethe effectiveness of force-titration of valsartan on VVI values in HF patients. Materials and Methods: In this multicenter and prospective observational trial, the effect of valsartan was stratified according todosages [non-ceiling dose (NCD) vs. ceiling dose (CD)] in HF patients with left ventricular ejection fraction (LVEF) <55%. Biochemicalstudies, including N-terminal pro-B-type natriuretic peptide (NT-proBNP), echocardiography with VVI, the treadmilltest, and the activity scale index were assessed at baseline and after 24 weeks of treatment. Results: One-hundred thirty-eight patients were force-titrated to either a CD group (n=81) or a NCD group (n=57). The mean age ofthe study participants was 59 years and 66% were male. After 6 months of follow up, left ventricular mass index (LVMI) values hadsignificantly improved in the CD group but not in the NCD group. Intriguingly, in HF patients with a reduced ejection fraction (HFrEF)(n=52, LVEF <40%), a significant improvement in VVI was only observed in the CD group (from 2.4±0.6 to 1.8±0.5, p<0.001). Conclusion: CDs of valsartan for 6 months showed better improvement in VVI, as well as LVMI, in patients with HFrEF, comparedwith NCDs. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | YONSEI UNIV COLL MEDICINE | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.title | Valsartan Dosage on Ventriculo-Vascular Coupling Index Dose-Dependency in Heart Failure Patients | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000649693300002 | - |
dc.identifier.doi | 10.3349/ymj.2021.62.5.391 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, v.62, no.5, pp.391 - 399 | - |
dc.identifier.kciid | ART002707908 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85105044310 | - |
dc.citation.endPage | 399 | - |
dc.citation.startPage | 391 | - |
dc.citation.title | YONSEI MEDICAL JOURNAL | - |
dc.citation.volume | 62 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | 안경진 | - |
dc.contributor.affiliatedAuthor | 유종욱 | - |
dc.contributor.affiliatedAuthor | 장영우 | - |
dc.contributor.affiliatedAuthor | 정욱진 | - |
dc.subject.keywordAuthor | Heart failure | - |
dc.subject.keywordAuthor | ventricular ejection fraction | - |
dc.subject.keywordAuthor | valsartan | - |
dc.subject.keywordAuthor | dosage | - |
dc.subject.keywordAuthor | ventriculo-vascular coupling index | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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