Long-term Outcome of Microscopic Transsphenoidal Surgery for Prolactinomas as an Alternative to Dopamine Agonists
DC Field | Value | Language |
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dc.contributor.author | Park Kawngwoo | - |
dc.contributor.author | Park Kwang Hyon | - |
dc.contributor.author | Park Hye Ran | - |
dc.contributor.author | Lee Jae Meen | - |
dc.contributor.author | Kim Yong Hwy | - |
dc.contributor.author | Kim Dong-Young | - |
dc.contributor.author | Won Tae-Bin | - |
dc.contributor.author | Kong Sung Hye | - |
dc.contributor.author | Kim Jung Hee | - |
dc.contributor.author | Shin Chan Soo | - |
dc.contributor.author | Paek Sun Ha | - |
dc.date.accessioned | 2021-05-24T03:40:07Z | - |
dc.date.available | 2021-05-24T03:40:07Z | - |
dc.date.created | 2021-04-20 | - |
dc.date.issued | 2021-04 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81069 | - |
dc.description.abstract | Background: Although long-term dopamine agonist (DA) therapy is recommended as a first-line treatment for prolactinoma, some patients may prefer surgical treatment because of the potential adverse effects of long-term medication, or the desire to become pregnant. This study aimed to determine whether surgical treatment of prolactinomas could be an alternative to DA therapy. Methods: In this retrospective study, 96 consecutive patients (74 female, 22 male) underwent primary pituitary surgery without long-term DA treatment for prolactinomas at a single institution from 1990 to 2010. All patients underwent primary surgical treatment in the microscopic transsphenoidal approach (TSA). Results: The median age and median follow-up period were 31 (16–73) years and 139.1 (12.2–319.6) months, respectively. An initial overall remission was accomplished in 47.9% (46 of 96 patients, 33 macroadenomas, and 13 microadenomas) of patients. DA dose reduction was achieved in all patients after TSA. A better remission rate was independently predicted by lower diagnostic prolactin levels and by a greater extent of surgical resection. Overall remission at the last follow-up was 33.3%, and the overall recurrence rate was 30.4%. The permanent complication rate was 3.1%, and there was no mortality. Conclusion: TSA can be considered a safe and potentially curative treatment for selective microprolactinomas as an alternative to treatment with a long-term DA. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.title | Long-term Outcome of Microscopic Transsphenoidal Surgery for Prolactinomas as an Alternative to Dopamine Agonists | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000646716500003 | - |
dc.identifier.doi | 10.3346/jkms.2021.36.e97 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.36, no.15, pp.1 - 10 | - |
dc.identifier.kciid | ART002706776 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85106133401 | - |
dc.citation.endPage | 10 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 36 | - |
dc.citation.number | 15 | - |
dc.contributor.affiliatedAuthor | Park Kawngwoo | - |
dc.subject.keywordAuthor | Pituitary Surgery | - |
dc.subject.keywordAuthor | Prolactinoma | - |
dc.subject.keywordAuthor | Dopamine Agonist | - |
dc.subject.keywordAuthor | Microscopic Transsphenoidal Surgery | - |
dc.subject.keywordPlus | COST-EFFECTIVENESS ANALYSIS | - |
dc.subject.keywordPlus | TRANS-SPHENOIDAL SURGERY | - |
dc.subject.keywordPlus | SURGICAL OUTCOMES | - |
dc.subject.keywordPlus | PITUITARY-ADENOMAS | - |
dc.subject.keywordPlus | MEDICAL-TREATMENT | - |
dc.subject.keywordPlus | CABERGOLINE | - |
dc.subject.keywordPlus | HYPERPROLACTINEMIA | - |
dc.subject.keywordPlus | WITHDRAWAL | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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