Development of Multi-layer Tubular Vascular Scaffold to Enhance Compliance by Exhibiting a Negative Poisson's Ratio
DC Field | Value | Language |
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dc.contributor.author | Ahn, Chi Bum | - |
dc.contributor.author | Kim, Joo Hyun | - |
dc.contributor.author | Lee, Ji-Hyun | - |
dc.contributor.author | Park, Kook Yang | - |
dc.contributor.author | Son, Kuk Hui | - |
dc.contributor.author | Lee, Jin Woo | - |
dc.date.accessioned | 2021-05-28T03:40:08Z | - |
dc.date.available | 2021-05-28T03:40:08Z | - |
dc.date.created | 2021-04-26 | - |
dc.date.issued | 2021-05 | - |
dc.identifier.issn | 2288-6206 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81104 | - |
dc.description.abstract | Synthetic small diameter vascular grafts frequently fail owing to intimal hyperplasia, results from mismatched compliance between the vascular graft and native vessels. A vascular graft with a negative Poisson's ratio (NPR, materials expand transversely when pulled axially) was suggested to enhance compliance. We produced a three-layer tubular vascular scaffold with NRP properties. The luminal side consisted of nanosized electrospun fibers for endothelial cell (EC) growth. The middle layer was an NPR structure created using 3D printing, and the outer layer was a microsized electrospun fiber layer for vascular smooth muscle cell (VSMC) growth. The developed multi-layer tubular vascular scaffold contained NPR value. And the NPR vascular scaffold showed 1.7 time higher compliance than the PPR scaffold and 3.8 times higher than that of commercial polytetrafluoroethylene (PTFE) vascular graft. In addition, the ECs and VSMCs were well survived and proliferated on the scaffold during 10 days of culture. From the optimized co-culture condition of the VSMCs and ECs that VSMC phenotype changed was inhibited, we successfully generated a thin luminal layer, which consisted of ECs and the proper thickness of the VSMC layer under the ECs. This scaffold may have a potential to replace conventional artificial vascular graft by providing enhanced compliance and improved cell culture environment. © 2021, Korean Society for Precision Engineering. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Korean Society for Precision Engineeing | - |
dc.relation.isPartOf | International Journal of Precision Engineering and Manufacturing - Green Technology | - |
dc.title | Development of Multi-layer Tubular Vascular Scaffold to Enhance Compliance by Exhibiting a Negative Poisson's Ratio | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000638021100003 | - |
dc.identifier.doi | 10.1007/s40684-021-00332-9 | - |
dc.identifier.bibliographicCitation | International Journal of Precision Engineering and Manufacturing - Green Technology, v.8, no.3, pp.841 - 853 | - |
dc.identifier.kciid | ART002715514 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85104251237 | - |
dc.citation.endPage | 853 | - |
dc.citation.startPage | 841 | - |
dc.citation.title | International Journal of Precision Engineering and Manufacturing - Green Technology | - |
dc.citation.volume | 8 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Ahn, Chi Bum | - |
dc.contributor.affiliatedAuthor | Kim, Joo Hyun | - |
dc.contributor.affiliatedAuthor | Lee, Ji-Hyun | - |
dc.contributor.affiliatedAuthor | Park, Kook Yang | - |
dc.contributor.affiliatedAuthor | Son, Kuk Hui | - |
dc.contributor.affiliatedAuthor | Lee, Jin Woo | - |
dc.type.docType | Article in Press | - |
dc.subject.keywordAuthor | 3D printing | - |
dc.subject.keywordAuthor | Co-culture | - |
dc.subject.keywordAuthor | Compliance | - |
dc.subject.keywordAuthor | Negative Poisson’s ratio | - |
dc.subject.keywordAuthor | Vascular scaffold | - |
dc.subject.keywordPlus | 3D printers | - |
dc.subject.keywordPlus | Cell culture | - |
dc.subject.keywordPlus | Electrospinning | - |
dc.subject.keywordPlus | Endothelial cells | - |
dc.subject.keywordPlus | Grafting (chemical) | - |
dc.subject.keywordPlus | Grafts | - |
dc.subject.keywordPlus | Muscle | - |
dc.subject.keywordPlus | Culture environments | - |
dc.subject.keywordPlus | Electrospun fibers | - |
dc.subject.keywordPlus | Intimal hyperplasia | - |
dc.subject.keywordPlus | Negative poisson&apos | - |
dc.subject.keywordPlus | s ratios | - |
dc.subject.keywordPlus | Polytetrafluoroethylene (PTFE) | - |
dc.subject.keywordPlus | Small diameter vascular grafts | - |
dc.subject.keywordPlus | Vascular scaffolds | - |
dc.subject.keywordPlus | Vascular Smooth Muscle Cells | - |
dc.subject.keywordPlus | Scaffolds (biology) | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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