Magnetic Resonance-Based Assessments Better Capture Pathophysiologic Profiles and Progression in Nonalcoholic Fatty Liver Disease
DC Field | Value | Language |
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dc.contributor.author | Choi, Seung Joon | - |
dc.contributor.author | Kim, Seong Min | - |
dc.contributor.author | Kim, Yun Soo | - |
dc.contributor.author | Kwon, Oh Sang | - |
dc.contributor.author | Shin, Seung Kak | - |
dc.contributor.author | Kim, Kyoung Kon | - |
dc.contributor.author | Lee, Ki Young | - |
dc.contributor.author | Park, Ie Byung | - |
dc.contributor.author | Choi, Cheol Soo | - |
dc.contributor.author | Chung, Dong Hae | - |
dc.contributor.author | Jung, Jaehun | - |
dc.contributor.author | MunYoung Paek | - |
dc.contributor.author | Lee, Dae Ho | - |
dc.date.accessioned | 2021-06-09T02:40:12Z | - |
dc.date.available | 2021-06-09T02:40:12Z | - |
dc.date.created | 2021-06-09 | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 2233-6079 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81221 | - |
dc.description.abstract | Background Several noninvasive tools are available for the assessment of nonalcoholic fatty liver disease (NAFLD) including clinical and blood biomarkers, transient elastography (TE), and magnetic resonance imaging (MRI) techniques, such as proton density fat fraction (MRI-PDFF) and magnetic resonance elastography (MRE). In the present study, we aimed to evaluate whether magnetic resonance (MR)-based examinations better discriminate the pathophysiologic features and fibrosis progression in NAFLD than other noninvasive methods. Methods A total of 133 subjects (31 healthy volunteers and 102 patients with NAFLD) were subjected to clinical and noninvasive NAFLD evaluation, with additional liver biopsy in some patients (n=54). Results MRI-PDFF correlated far better with hepatic fat measured by MR spectroscopy (r=0.978, P<0.001) than with the TE controlled attenuation parameter (CAP) (r=0.727, P<0.001). In addition, MRI-PDFF showed stronger correlations with various pathophysiologic parameters for cellular injury, glucose and lipid metabolism, and inflammation, than the TE-CAP. The MRI-PDFF and TE-CAP cutoff levels associated with abnormal elevation of serum alanine aminotransferase were 9.9% and 270 dB/m, respectively. The MRE liver stiffness measurement (LSM) showed stronger correlations with liver enzymes, platelets, complement component 3, several clinical fibrosis scores, and the enhanced liver fibrosis (ELF) score than the TE-LSM. In an analysis of only biopsied patients, MRE performed better in discriminating advanced fibrosis with a cutoff value of 3.9 kPa than the TE (cutoff 8.1 kPa) and ELF test (cutoff 9.2 kPa). Conclusion Our results suggest that MRI-based assessment of NAFLD is the best non-invasive tool that captures the histologic, pathophysiologic and metabolic features of the disease. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Korean Diabetes Association | - |
dc.relation.isPartOf | Diabetes & Metabolism Journal | - |
dc.title | Magnetic Resonance-Based Assessments Better Capture Pathophysiologic Profiles and Progression in Nonalcoholic Fatty Liver Disease | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000727249400011 | - |
dc.identifier.doi | 10.4093/dmj.2020.0137 | - |
dc.identifier.bibliographicCitation | Diabetes & Metabolism Journal, v.45, no.5, pp.739 - 752 | - |
dc.identifier.kciid | ART002761432 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85115054933 | - |
dc.citation.endPage | 752 | - |
dc.citation.startPage | 739 | - |
dc.citation.title | Diabetes & Metabolism Journal | - |
dc.citation.volume | 45 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Choi, Seung Joon | - |
dc.contributor.affiliatedAuthor | Kim, Seong Min | - |
dc.contributor.affiliatedAuthor | Kim, Yun Soo | - |
dc.contributor.affiliatedAuthor | Kwon, Oh Sang | - |
dc.contributor.affiliatedAuthor | Shin, Seung Kak | - |
dc.contributor.affiliatedAuthor | Kim, Kyoung Kon | - |
dc.contributor.affiliatedAuthor | Lee, Ki Young | - |
dc.contributor.affiliatedAuthor | Park, Ie Byung | - |
dc.contributor.affiliatedAuthor | Choi, Cheol Soo | - |
dc.contributor.affiliatedAuthor | Chung, Dong Hae | - |
dc.contributor.affiliatedAuthor | Jung, Jaehun | - |
dc.contributor.affiliatedAuthor | Lee, Dae Ho | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Elasticity imaging techniques | - |
dc.subject.keywordAuthor | Magnetic resonance imaging | - |
dc.subject.keywordAuthor | Non-alcoholic fatty liver disease | - |
dc.subject.keywordPlus | CONTROLLED ATTENUATION PARAMETER | - |
dc.subject.keywordPlus | TRANSIENT ELASTOGRAPHY | - |
dc.subject.keywordPlus | STIFFNESS MEASUREMENT | - |
dc.subject.keywordPlus | HEPATIC STEATOSIS | - |
dc.subject.keywordPlus | FIBROSIS | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | PERFORMANCE | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | VALIDATION | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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