Prediction of Early Recanalization after Intravenous Thrombolysis in Patients with Large-Vessel Occlusion
DC Field | Value | Language |
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dc.contributor.author | Kim, Young Dae | - |
dc.contributor.author | Nam, Hyo Suk | - |
dc.contributor.author | Yoo, Joonsang | - |
dc.contributor.author | Park, Hyungjong | - |
dc.contributor.author | Sohn, Sung-Il | - |
dc.contributor.author | Hong, Jeong-Ho | - |
dc.contributor.author | Kim, Byung Moon | - |
dc.contributor.author | Kim, Dong Joon | - |
dc.contributor.author | Bang, Oh Young | - |
dc.contributor.author | Seo, Woo-Keun | - |
dc.contributor.author | Chung, Jong-Won | - |
dc.contributor.author | Lee, Kyung-Yul | - |
dc.contributor.author | Jung, Yo Han | - |
dc.contributor.author | Lee, Hye Sun | - |
dc.contributor.author | Ahn, Seong Hwan | - |
dc.contributor.author | Shin, Dong Hoon | - |
dc.contributor.author | Choi, Hye-Yeon | - |
dc.contributor.author | Cho, Han-Jin | - |
dc.contributor.author | Baek, Jang-Hyun | - |
dc.contributor.author | Kim, Gyu Sik | - |
dc.contributor.author | Seo, Kwon-Duk | - |
dc.contributor.author | Kim, Seo Hyun | - |
dc.contributor.author | Song, Tae-Jin | - |
dc.contributor.author | Kim, Jinkwon | - |
dc.contributor.author | Han, Sang Won | - |
dc.contributor.author | Park, Joong Hyun | - |
dc.contributor.author | Lee, Sung Ik | - |
dc.contributor.author | Heo, JoonNyung | - |
dc.contributor.author | Choi, Jin Kyo | - |
dc.contributor.author | Heo, Ji Hoe | - |
dc.date.accessioned | 2021-06-14T02:40:19Z | - |
dc.date.available | 2021-06-14T02:40:19Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2021-05 | - |
dc.identifier.issn | 2287-6391 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81273 | - |
dc.description.abstract | Background and Purpose We aimed to develop a model predicting early recanalization after in-travenous tissue plasminogen activator (t-PA) treatment in large-vessel occlusion. Methods Using data from two different multicenter prospective cohorts, we determined the fac-tors associated with early recanalization immediately after t-PA in stroke patients with large-ves-sel occlusion, and developed and validated a prediction model for early recanalization. Clot volume was semiautomatically measured on thin-section computed tomography using software, and the degree of collaterals was determined using the Tan score. Follow-up angiographic studies were performed immediately after t-PA treatment to assess early recanalization. Results Early recanalization, assessed 61.0 +/- 44.7 minutes after t-PA bolus, was achieved in 15.5% (15/97) in the derivation cohort and in 10.5% (8/76) in the validation cohort. Clot volume (odds ratio [OR], 0.979; 95% confidence interval [CI], 0.961 to 0.997; P=0.020) and good collaterals (OR, 6.129; 95% CI, 1.592 to 23.594; P=0.008) were significant factors associated with early recanalization. The area under the curve (AUC) of the model including clot volume was 0.819 (95% CI, 0.720 to 0.917) and 0.842 (95% CI, 0.746 to 0.938) in the derivation and validation cohorts, respectively. The AUC improved when good collaterals were added (derivation cohort: AUC, 0.876; 95% CI, 0.802 to 0.950; P=0.164; validation cohort: AUC, 0.949; 95% CI, 0.886 to 1.000; P=0.036). The integrated discrimination improvement also showed significantly improved prediction (0.097; 95% CI, 0.009 to 0.185; P=0.032). Conclusions The model using clot volume and collaterals predicted early recanalization after intravenous t-PA and had a high performance. This model may aid in determining the recanalization treatment strategy in stroke patients with large-vessel occlusion. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN STROKE SOC | - |
dc.relation.isPartOf | JOURNAL OF STROKE | - |
dc.title | Prediction of Early Recanalization after Intravenous Thrombolysis in Patients with Large-Vessel Occlusion | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000656888500009 | - |
dc.identifier.doi | 10.5853//jos.2020.03622 | - |
dc.identifier.bibliographicCitation | JOURNAL OF STROKE, v.23, no.2, pp.244 - 252 | - |
dc.identifier.kciid | ART002721289 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85108209429 | - |
dc.citation.endPage | 252 | - |
dc.citation.startPage | 244 | - |
dc.citation.title | JOURNAL OF STROKE | - |
dc.citation.volume | 23 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Shin, Dong Hoon | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Ischemia | - |
dc.subject.keywordAuthor | Stroke | - |
dc.subject.keywordAuthor | Thrombosis | - |
dc.subject.keywordAuthor | Thrombolysis | - |
dc.subject.keywordAuthor | Reperfusion | - |
dc.subject.keywordPlus | ACUTE ISCHEMIC-STROKE | - |
dc.subject.keywordPlus | CLOT BURDEN SCORE | - |
dc.subject.keywordPlus | MECHANICAL THROMBECTOMY | - |
dc.subject.keywordPlus | THROMBUS | - |
dc.subject.keywordPlus | CIRCULATION | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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