Cinnamomum loureirii Extract Inhibits Acetylcholinesterase Activity and Ameliorates Trimethyltin-Induced Cognitive Dysfunction in Mice
DC Field | Value | Language |
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dc.contributor.author | Kim, Cho Rong | - |
dc.contributor.author | Choi, Soo Jung | - |
dc.contributor.author | Kwon, Yoon Kyung | - |
dc.contributor.author | Kim, Jae Kyeom | - |
dc.contributor.author | Kim, Youn-Jung | - |
dc.contributor.author | Park, Gwi Gun | - |
dc.contributor.author | Shin, Dong-Hoon | - |
dc.date.available | 2020-02-28T01:43:23Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2016-07 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8133 | - |
dc.description.abstract | The pathogenesis of Alzheimer's disease (AD) has been linked to the deficiency of neurotransmitter acetylcholine (ACh) in the brain, and the main treatment strategy for improving AD symptoms is the inhibition of acetylcholinesterase (AChE) activity. In the present study, we aimed to identify potent AChE inhibitors from Cinnamomum loureirii extract via bioassay-guided fractionation. We demonstrated that the most potent AChE inhibitor present in the C. loureirii extract was 2,4-bis(1,1-dimethylethyl)phenol. To confirm the antiamnesic effects of the ethanol extract of C. loureirii, mice were intraperitoneally injected with the neurotoxin trimethyltin (2.5mg/kg) to induce cognitive dysfunction, and performance in the Y-maze and passive avoidance tests was assessed. Treatment with C. loureirii extract significantly improved performance in both behavioral tests, suggesting that this extract may be neuroprotective and therefore beneficial in preventing or ameliorating the degenerative processes of AD, potentially by restoring cholinergic function. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PHARMACEUTICAL SOC JAPAN | - |
dc.relation.isPartOf | BIOLOGICAL & PHARMACEUTICAL BULLETIN | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | CHOLINESTERASE-INHIBITORS | - |
dc.subject | 2,4-DI-TERT-BUTYLPHENOL | - |
dc.subject | DERIVATIVES | - |
dc.title | Cinnamomum loureirii Extract Inhibits Acetylcholinesterase Activity and Ameliorates Trimethyltin-Induced Cognitive Dysfunction in Mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000378974400008 | - |
dc.identifier.doi | 10.1248/bpb.b16-00045 | - |
dc.identifier.bibliographicCitation | BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.39, no.7, pp.1130 - 1136 | - |
dc.identifier.scopusid | 2-s2.0-84978035518 | - |
dc.citation.endPage | 1136 | - |
dc.citation.startPage | 1130 | - |
dc.citation.title | BIOLOGICAL & PHARMACEUTICAL BULLETIN | - |
dc.citation.volume | 39 | - |
dc.citation.number | 7 | - |
dc.contributor.affiliatedAuthor | Park, Gwi Gun | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | Cinnamomum loureirii | - |
dc.subject.keywordAuthor | acetylcholine | - |
dc.subject.keywordAuthor | acetylcholinesterase inhibitor | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | CHOLINESTERASE-INHIBITORS | - |
dc.subject.keywordPlus | 2,4-DI-TERT-BUTYLPHENOL | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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