Bioactive compounds isolated from defatted microalgal biomasses of botryococcus braunii and dunaliella tertiolecta showing a tyrosinase inhibitory activity
- Authors
- Lee, Da G.; Kashif, Shaheen A.; Yoo, Ah Y.; Choi, Ji W.; Park, Yong I.; Synytsya, Andriy; Park, Jae K.
- Issue Date
- May-2021
- Publisher
- Bentham Science Publishers
- Keywords
- Antioxidant; Biomasses; Microalgae; Substrate specificity; Tyrosinase; Water-soluble macromolecule
- Citation
- Current Bioactive Compounds, v.17, no.3, pp.234 - 245
- Journal Title
- Current Bioactive Compounds
- Volume
- 17
- Number
- 3
- Start Page
- 234
- End Page
- 245
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81352
- DOI
- 10.2174/1573407216999200515095507
- ISSN
- 1573-4072
- Abstract
- Aims: This study aims to elucidate the structural difference and biochemical properties of bioactive compounds of microalgal biomasses. Background: The structural difference and biochemical properties of bioactive compounds termed as Water-Soluble Macromolecules (WSMs) are interested in evaluating their biological activities. Methods: This study was performed to elucidate the structural difference and biochemical properties of bioactive compounds termed as Water-Soluble Macromolecules (WSMs) isolated from de-fatted microalgal biomasses of Botryococcus braunii and Dunaliella tertiolecta. Results: The compositional analysis of both WSMs revealed that WSM-Bb is a hetero-macro-molecule consisting of various monosaccharides, whereas WSM-Dt was characterized as a homo--macromolecule that mainly consists of glucose. Interestingly, WSM-Bb showed the significant ty-rosinase inhibitory activity with the increase of both the concentration and reaction time. Whereas there was no significant inhibitory activity observed by WSM-Dt. Conclusion: Inhibitory action of WSM-Bb toward both tyrosinase and tyrosine in either simultaneous or separate reaction may be mainly due to the physical affinity of WSM-Bb. These results em-phasize the identification of the primary components of these WSMs and their relevance with the antioxidant function. © 2021 Bentham Science Publishers.
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