Response to neoadjuvant chemotherapy based on pathologic complete response in very young patients with ER-positive breast cancer: a large, multicenter, observational study
DC Field | Value | Language |
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dc.contributor.author | Woo, Joohyun | - |
dc.contributor.author | Oh, Se Jeong | - |
dc.contributor.author | Song, Jeong-Yoon | - |
dc.contributor.author | Chae, Byung Joo | - |
dc.contributor.author | Choi, Jung Eun | - |
dc.contributor.author | Lee, Jeeyeon | - |
dc.contributor.author | Park, Heung Kyu | - |
dc.contributor.author | Lim, Woosungf | - |
dc.date.accessioned | 2021-06-22T03:40:04Z | - |
dc.date.available | 2021-06-22T03:40:04Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2021-05-31 | - |
dc.identifier.issn | 1471-2407 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81356 | - |
dc.description.abstract | Background: In estrogen receptor (ER)-positive breast cancer (BC), young age is associated with poor prognosis. While very young patients respond better to chemotherapy, chemotherapy is less effective in ER-positive tumors than in ER-negative tumors. The authors tried to evaluate chemotherapy response of very young patients with ER-positive BC by pathologic complete response (pCR) after neoadjuvant chemotherapy excluding the effect of endocrine treatment to the extent possible. Methods: We collected individual patient data from 1992 to 2013 from the Korean Breast Cancer Society (KBCS). Total 1048 ER-positive and 797 ER-negative patients aged < 50 years who had been treated with neoadjuvant chemotherapy were included for analysis. We compared pCR rate between patients aged < 35 years with ER-positive tumors and the other groups. Results: The proportion of patients aged < 35 years was 14.0% of patients with ER-positive BC in this cohort of under 50 years old, and 16.8% of patients with ER-negative BC in this cohort of under 50 years old. Although most characteristics of tumors according to age were comparable, tumors with high Ki-67 expression were more common in patients aged < 35 years than in patients aged 35-49 years in both ER-positive and -negative group (P = 0.001). Breast conservation rates were not significantly different according to age (44.2% vs. 46.8% in ER-positive group, 55.2% vs. 48.0% in ER-negative group). pCR rate was not different according to age in ER-positive group (P = 0.71) but significantly better in patients aged < 35 years in ER-negative group (P = 0.009). After adjusting for confounding variables, young patients maintained the higher probability of pCR than older patients in ER-negative tumors. However, pCR rate did not differ according to age in ER-positive tumors. In multivariate analysis, young age (< 35 years) was correlated with poor overall survival (P = 0.003, HR = 1.98) and there was only one event in a few patients achieved pCR in ER-positive group. Conclusions: Chemotherapy response based on pCR was not better in young patients (< 35 years) with ER-positive BC than in older premenopausal patients with non-metastatic ER-positive BC. Young age cannot be a predictive factor of response to neoadjuvant chemotherapy in ER-positive BC. Different biological characteristics such as high proliferative index should be considered. Trial registration: Retrospectively registered. © 2021, The Author(s). | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.relation.isPartOf | BMC CANCER | - |
dc.title | Response to neoadjuvant chemotherapy based on pathologic complete response in very young patients with ER-positive breast cancer: a large, multicenter, observational study | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000659118600001 | - |
dc.identifier.doi | 10.1186/s12885-021-08355-w | - |
dc.identifier.bibliographicCitation | BMC CANCER, v.21, no.1 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85107322305 | - |
dc.citation.title | BMC CANCER | - |
dc.citation.volume | 21 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Park, Heung Kyu | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Breast cancer | - |
dc.subject.keywordAuthor | ER-positive | - |
dc.subject.keywordAuthor | Neoadjuvant chemotherapy | - |
dc.subject.keywordAuthor | Pathologic complete response | - |
dc.subject.keywordAuthor | Young patients | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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