Anti-inflammatory effects of oroxylin A on RAW 264.7 mouse macrophages induced with polyinosinic-polycytidylic acid
DC Field | Value | Language |
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dc.contributor.author | Lee, Ji Young | - |
dc.contributor.author | Park, Wansu | - |
dc.date.available | 2020-02-28T01:43:27Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2016-07 | - |
dc.identifier.issn | 1792-0981 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8138 | - |
dc.description.abstract | Oroxylin A (5,7dihydroxy-6-methoxy-2-phe-nylchromen-4-one; Baicalein 6-methyl ether) is an active flavonoid compound originally isolated from Scutellaria radix, which has been used to treat pulmonary infection in Korea, China, and Japan. Oroxylin A is known to possess dopamine reuptake inhibitor activity. However, the effects of oroxylin A on virus-induced macrophages has not been fully elucidated. In the present study, the anti-inflammatory effects of oroxylin A on double-stranded RNA-induced macrophages were examined. Production of nitric oxide (NO), various cytokines, as well as calcium release and the mRNA expression of signal transducer and activator of transcription 1 (STAT1) in dsRNA polyinosinic-polycytidylic acid (PIC) -induced RAW 264.7 mouse macrophages were evaluated. Oroxylin A restored the cell viability in PIC-induced RAW 264.7 mouse macrophages at concentrations of up to 50 mu M. Additionally, oroxylin A significantly inhibited the production of nitric oxide (NO), interleukin (IL) -1 alpha, IL-1 beta, IL-6, IL-10, interferon gamma-induced protein 10, granulocyte-colony stimulating factor (CSF), granulocyte macrophage-CSF, leukemia inhibitory factor (IL-6 class cytokine), lipopolysaccharide-induced CXC chemokine (LIX), monocyte chemoattractant protein 1, macrophage inflammatory protein (MIP) -1 alpha, MIP-1 beta, MIP-2, Regulated on Activation, Normal T Expressed and Secreted, tumor necrosis factor-a, and vascular endothelial growth factor as well as calcium release and the mRNA expression of STAT1 in PIC-induced RAW 264.7 cells (P<0.05). Thus, the present results suggest that oroxylin A has anti-inflammatory properties, associated with its inhibition of NO, cytokines, chemokines and growth factors in PIC-induced macrophages via the calcium-STAT pathway. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.relation.isPartOf | EXPERIMENTAL AND THERAPEUTIC MEDICINE | - |
dc.subject | WATER EXTRACT | - |
dc.subject | EXPRESSION | - |
dc.subject | ACTIVATION | - |
dc.subject | INFLAMMATION | - |
dc.subject | APOPTOSIS | - |
dc.subject | SEPSIS | - |
dc.subject | CELLS | - |
dc.subject | MICE | - |
dc.subject | WOGONIN | - |
dc.subject | INDICUM | - |
dc.title | Anti-inflammatory effects of oroxylin A on RAW 264.7 mouse macrophages induced with polyinosinic-polycytidylic acid | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000378262300022 | - |
dc.identifier.doi | 10.3892/etm.2016.3320 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND THERAPEUTIC MEDICINE, v.12, no.1, pp.151 - 156 | - |
dc.identifier.scopusid | 2-s2.0-84968807150 | - |
dc.citation.endPage | 156 | - |
dc.citation.startPage | 151 | - |
dc.citation.title | EXPERIMENTAL AND THERAPEUTIC MEDICINE | - |
dc.citation.volume | 12 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Lee, Ji Young | - |
dc.contributor.affiliatedAuthor | Park, Wansu | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | oroxylin A | - |
dc.subject.keywordAuthor | double stranded-RNA | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | macrophages | - |
dc.subject.keywordAuthor | nitric oxide | - |
dc.subject.keywordAuthor | cytokine | - |
dc.subject.keywordAuthor | calcium | - |
dc.subject.keywordAuthor | signal transducer and activated transcription 1 | - |
dc.subject.keywordPlus | WATER EXTRACT | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | SEPSIS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | WOGONIN | - |
dc.subject.keywordPlus | INDICUM | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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