A Brief Review of the Mechanisms of beta-Cell Dedifferentiation in Type 2 Diabetes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Khin, Phyu-Phyu | - |
dc.contributor.author | Lee, Jong-Han | - |
dc.contributor.author | Jun, Hee-Sook | - |
dc.date.accessioned | 2021-06-30T01:40:09Z | - |
dc.date.available | 2021-06-30T01:40:09Z | - |
dc.date.created | 2021-05-20 | - |
dc.date.issued | 2021-05 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81396 | - |
dc.description.abstract | Diabetes is a metabolic disease characterized by hyperglycemia. Over 90% of patients with diabetes have type 2 diabetes. Pancreatic β-cells are endocrine cells that produce and secrete insulin, an essential endocrine hormone that regulates blood glucose levels. Deficits in β-cell function and mass play key roles in the onset and progression of type 2 diabetes. Apoptosis has been considered as the main contributor of β-cell dysfunction and decrease in β-cell mass for a long time. However, recent studies suggest that β-cell failure occurs mainly due to increased β-cell dedifferentiation rather than limited β-cell proliferation or increased β-cell death. In this review, we summarize the current advances in the understanding of the pancreatic β-cell dedifferentiation process including potential mechanisms. A better understanding of β-cell dedifferentiation process will help to identify novel therapeutic targets to prevent and/or reverse β-cell loss in type 2 diabetes. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | NUTRIENTS | - |
dc.title | A Brief Review of the Mechanisms of beta-Cell Dedifferentiation in Type 2 Diabetes | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000662420000001 | - |
dc.identifier.doi | 10.3390/nu13051593 | - |
dc.identifier.bibliographicCitation | NUTRIENTS, v.13, no.5 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85105524876 | - |
dc.citation.title | NUTRIENTS | - |
dc.citation.volume | 13 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Khin, Phyu-Phyu | - |
dc.contributor.affiliatedAuthor | Jun, Hee-Sook | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | ER stress | - |
dc.subject.keywordAuthor | Long non-coding RNAs | - |
dc.subject.keywordAuthor | MicroRNAs | - |
dc.subject.keywordAuthor | Oxidative stress | - |
dc.subject.keywordAuthor | Type 2 diabetes | - |
dc.subject.keywordAuthor | β-cell dedifferentiation | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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