Identification of gallic acid as a active ingredient of Syzygium aromaticum against tacrolimus-induced damage in renal epithelial LLC-PK1 cells and rat kidney
DC Field | Value | Language |
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dc.contributor.author | Lee, Ji Hwan | - |
dc.contributor.author | Park, Musun | - |
dc.contributor.author | Jung, Kiwon | - |
dc.contributor.author | Hong, Gyeongmin | - |
dc.contributor.author | Lee, Hye Lim | - |
dc.contributor.author | Kim, Dong-Wook | - |
dc.contributor.author | Kim, Chang-Eop | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.date.accessioned | 2021-07-04T05:41:30Z | - |
dc.date.available | 2021-07-04T05:41:30Z | - |
dc.date.created | 2021-05-17 | - |
dc.date.issued | 2021-06-01 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81528 | - |
dc.description.abstract | Tacrolimus (FK506), a calcineurin inhibitor, is an effective immunosuppressive agent mainly used to lower the risk of organ rejection after allogeneic organ transplant. However, FK506-associated adverse effects, such as nephrotoxicity, may limit its therapeutic use. In this study, we confirmed that epigallocatechin-3-gallate (EGCG), sanguiin H-6, and gallic acid increased cell survival following FK506-induced cytotoxicity in renal epithelial LLC-PK1. Among these compounds, gallic acid exerted the strongest protective effect, further confirmed in the FK506-induced nephrotoxicity rat model. Additionally, we identified supporting evidence for the nephroprotective function of gallic acid using molecular docking and bioavailability investigations. © 2021 Elsevier Ltd | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.title | Identification of gallic acid as a active ingredient of Syzygium aromaticum against tacrolimus-induced damage in renal epithelial LLC-PK1 cells and rat kidney | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000651231100007 | - |
dc.identifier.doi | 10.1016/j.bmcl.2021.128012 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.41 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85105337821 | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.volume | 41 | - |
dc.contributor.affiliatedAuthor | Lee, Ji Hwan | - |
dc.contributor.affiliatedAuthor | Park, Musun | - |
dc.contributor.affiliatedAuthor | Kim, Chang-Eop | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | FK506 | - |
dc.subject.keywordAuthor | Gallic acid | - |
dc.subject.keywordAuthor | Nephrotoxicity | - |
dc.subject.keywordAuthor | Tacrolimus | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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