Liquid Crystal-Based Droplet Sensor for the Detection of Hg(II) Ions Using an Aptamer as the Recognition Element
DC Field | Value | Language |
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dc.contributor.author | Hong, P.T.K. | - |
dc.contributor.author | Yun, Kyusik | - |
dc.contributor.author | Jang, Chang-Hyun | - |
dc.date.accessioned | 2021-07-04T05:41:57Z | - |
dc.date.available | 2021-07-04T05:41:57Z | - |
dc.date.created | 2021-03-02 | - |
dc.date.issued | 2021-06 | - |
dc.identifier.issn | 1976-0280 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81535 | - |
dc.description.abstract | Herein, we report the development of a simple liquid crystal (LC)-based droplet sensor for the specific detection of mercury ions (Hg2+) in an aqueous medium, using trimethyl octadecyl ammonium bromide (OTAB) and an Hg2+-binding aptamer. In terms of the mechanism, the system senses the homeotropic orientation of the LCs at the LC–aqueous interface that is induced by the self-assembled monolayer of positively charged OTAB molecules. In the absence of Hg2+, electrostatic interactions between the positively charged OTAB and negatively charged aptamer molecules disturb the organization of the OTAB monolayer, causing the LCs to adopt a planar orientation. By contrast, an aptamer hairpin structure formed in the presence of Hg2+ weakens the interactions between the OTAB and aptamer molecules, causing the OTAB monolayer to self-reassemble and the LCs to consequently adopt a homeotropic orientation. These LC orientational transitions are observable under a polarized optical microscope. This sensor had a low limit of detection of 100 and 250 pM for buffer and tap water samples, respectively. Therefore, our LC-based droplet sensor is a suitable platform for the simple, specific, and convenient detection of Hg2+ in an aqueous medium. © 2021, The Korean BioChip Society. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN BIOCHIP SOCIETY-KBCS | - |
dc.relation.isPartOf | BIOCHIP JOURNAL | - |
dc.title | Liquid Crystal-Based Droplet Sensor for the Detection of Hg(II) Ions Using an Aptamer as the Recognition Element | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000618183000004 | - |
dc.identifier.doi | 10.1007/s13206-021-00010-7 | - |
dc.identifier.bibliographicCitation | BIOCHIP JOURNAL, v.15, no.2, pp.152 - 161 | - |
dc.identifier.kciid | ART002725398 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85100880556 | - |
dc.citation.endPage | 161 | - |
dc.citation.startPage | 152 | - |
dc.citation.title | BIOCHIP JOURNAL | - |
dc.citation.volume | 15 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Hong, P.T.K. | - |
dc.contributor.affiliatedAuthor | Yun, Kyusik | - |
dc.contributor.affiliatedAuthor | Jang, Chang-Hyun | - |
dc.type.docType | Article in Press | - |
dc.subject.keywordAuthor | 4-cyano-4′-pentylbiphenyl | - |
dc.subject.keywordAuthor | Detection of Hg2+ | - |
dc.subject.keywordAuthor | Liquid crystal-based droplet sensor | - |
dc.subject.keywordAuthor | Liquid crystals | - |
dc.subject.keywordAuthor | Mercury ions | - |
dc.subject.keywordPlus | Chromium compounds | - |
dc.subject.keywordPlus | Drops | - |
dc.subject.keywordPlus | Liquid crystals | - |
dc.subject.keywordPlus | Molecules | - |
dc.subject.keywordPlus | Monolayers | - |
dc.subject.keywordPlus | Phase interfaces | - |
dc.subject.keywordPlus | Homeotropic orientation | - |
dc.subject.keywordPlus | Limit of detection | - |
dc.subject.keywordPlus | Negatively charged | - |
dc.subject.keywordPlus | Orientational transitions | - |
dc.subject.keywordPlus | Planar orientation | - |
dc.subject.keywordPlus | Polarized optical microscopes | - |
dc.subject.keywordPlus | Positively charged | - |
dc.subject.keywordPlus | Recognition element | - |
dc.subject.keywordPlus | Mercury compounds | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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