Early-stage Parkinson's disease: Abnormal nigrosome 1 and 2 revealed by a voxelwise analysis of neuromelanin-sensitive MRI
DC Field | Value | Language |
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dc.contributor.author | Sung, Young Hee | - |
dc.contributor.author | Noh, Young | - |
dc.contributor.author | Kim, Eung Yeop | - |
dc.date.accessioned | 2021-07-04T07:41:45Z | - |
dc.date.available | 2021-07-04T07:41:45Z | - |
dc.date.created | 2021-03-18 | - |
dc.date.issued | 2021-06 | - |
dc.identifier.issn | 1065-9471 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81564 | - |
dc.description.abstract | Previous pathologic studies evaluated the substantia nigra pars compacta (SNpc) of a limited number of idiopathic Parkinson's disease (IPD) patients with relatively longer disease durations. Therefore, it remains unknown which region of the SNpc is most significantly affected in early-stage IPD. We hypothesized that a voxelwise analysis of thin-section neuromelanin-sensitive MRI (NM-MRI) may help determine the significantly affected regions of the SNpc in early-stage IPD and localize these areas in each nigrosome on high-spatial-resolution susceptibility map-weighted imaging (SMwI). Ninety-six healthy subjects and 50 early-stage IPD patients underwent both a 0.8 × 0.8 × 0.8 mm3 NM-MRI and a 0.5 × 0.5 × 1.0 mm3 multi-echo gradient-recalled echo imaging for SMwI. Both NM-MRI and SMwI templates were created by using image data from the 96 healthy subjects. Permutation-based nonparametric tests were conducted to investigate spatial differences between the two groups in NM-MRI, and the results were displayed on both NM-MRI and SMwI templates. The posterolateral and anteromedial regions of the SNpc in NM-MRI were significantly different between the two groups, corresponding to the nigrosome 1 and nigrosome 2 regions, respectively, on the SMwI template. There were the areas of significant spatial difference in the hypointense SN on SMwI between early-stage IPD patients and healthy subjects. These areas on SMwI were slightly greater than those on NM-MRI, including the areas showing group difference on NM-MRI. Our voxelwise analysis of NM-MRI suggests that two regions (nigrosome 1 and nigrosome 2) of the SNpc are separately affected in early-stage IPD. © 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.relation.isPartOf | Human Brain Mapping | - |
dc.title | Early-stage Parkinson's disease: Abnormal nigrosome 1 and 2 revealed by a voxelwise analysis of neuromelanin-sensitive MRI | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000626910900001 | - |
dc.identifier.doi | 10.1002/hbm.25406 | - |
dc.identifier.bibliographicCitation | Human Brain Mapping, v.42, no.9, pp.2823 - 2832 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85102287291 | - |
dc.citation.endPage | 2832 | - |
dc.citation.startPage | 2823 | - |
dc.citation.title | Human Brain Mapping | - |
dc.citation.volume | 42 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Sung, Young Hee | - |
dc.contributor.affiliatedAuthor | Noh, Young | - |
dc.contributor.affiliatedAuthor | Kim, Eung Yeop | - |
dc.type.docType | Article in Press | - |
dc.subject.keywordAuthor | magnetic resonance imaging | - |
dc.subject.keywordAuthor | neuromelanin | - |
dc.subject.keywordAuthor | nigrosome | - |
dc.subject.keywordAuthor | Parkinson disease | - |
dc.subject.keywordAuthor | substantia nigra pars compacta | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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